Nitrofurantoin Olikla (Nitrofurantoin, Macrocrystalline)

Nitrofurantoin, the active ingredient in Nitrofurantoin Olikla, is a nitrofuran antibiotic presented as a tablet for oral use. It exerts bactericidal activity in the urinary tract and is indicated for the treatment of uncomplicated urinary tract infections, such as acute cystitis, in adult patients.

GNH USA supplies Nitrofurantoin Olikla as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides regulatory documentation to support global distribution through reliable logistics networks.

Nitrofurantoin is a nitrofuran antibiotic used to treat infections of the urinary tract.

- Uncomplicated urinary tract infection (cystitis): eradicates the causative bacteria and resolves urinary symptoms. - Acute uncomplicated lower urinary tract infection: provides rapid bactericidal activity in the bladder. - Prevention of recurrent urinary tract infections: used as a prophylactic agent to reduce the frequency of future episodes.

Nitrofurantoin may cause a range of adverse reactions, most of which are mild and reversible.

Common Side Effects: - Nausea: mild to moderate upset stomach. - Loss of appetite: reduced desire to eat. - Headache: transient cranial discomfort. - Urine discoloration: brownish or dark urine without clinical significance.

Serious or Rare Side Effects: - Pulmonary toxicity: interstitial pneumonitis or fibrosis requiring immediate medical attention. - Hepatic injury: hepatitis or liver enzyme elevation. - Hemolytic anemia: especially in patients with G6PD deficiency.

Before prescribing Nitrofurantoin, clinicians should consider several safety aspects.

- Renal function: avoid use in patients with severely reduced creatinine clearance (<30 mL/min). - G6PD deficiency: contraindicated due to risk of hemolysis. - Pregnancy: use only if clearly needed; safety category is unknown. - Elderly patients: monitor for pulmonary and hepatic adverse effects. - Drug hypersensitivity: discontinue if rash or allergic reaction occurs. - Store at ambient temperature: keep below 25 °C, retain in original packaging, and protect from moisture.

Nitrofurantoin can interact with other medicines, altering its efficacy or safety.

Major Interactions (Avoid): - Antacids containing magnesium or aluminum: reduce absorption of nitrofurantoin. - Probenecid: decreases renal excretion, increasing systemic exposure. - Fluoroquinolones: additive risk of tendon toxicity.

Moderate Interactions (Monitor Closely): - Warfarin: may enhance anticoagulant effect; monitor INR. - Diuretics: may affect renal clearance and increase toxicity risk. - Oral contraceptives: potential reduction in contraceptive efficacy.