Nitrofurantoin Agepha

Nitrofurantoin, the active ingredient in Nitrofurantoin Agepha, is a nitrofuran antibiotic presented as an oral tablet for oral use. It treats uncomplicated urinary tract infections in adult patients by inhibiting bacterial enzyme systems that are essential for bacterial growth.

GNH USA supplies Nitrofurantoin Agepha as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to strict quality standards and provides regulatory documentation for global distribution.

Nitrofurantoin is used to treat infections of the urinary tract, targeting bacterial pathogens that cause cystitis and related conditions.

Uncomplicated cystitis: resolves infection symptoms and eradicates causative bacteria. Acute uncomplicated urinary tract infection: provides bacteriological cure and symptom relief. Prevention of recurrent urinary tract infection: reduces frequency of infection episodes when used as prophylaxis.

Nitrofurantoin may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects: - Nausea - Diarrhea - Headache - Metallic taste in mouth

Serious or Rare Side Effects: - Pulmonary toxicity (interstitial pneumonitis) - Liver injury (hepatitis, jaundice) - Hemolytic anemia in patients with G6PD deficiency

When prescribing Nitrofurantoin, several safety considerations should be observed.

Renal function assessment: ensure creatinine clearance is ≥60 mL/min before initiating therapy. Severe renal impairment: avoid use in patients with markedly reduced kidney function. Pregnancy: use only if benefits outweigh potential risks, as safety data are limited. G6PD deficiency: monitor for signs of hemolysis and discontinue if observed. Allergic reactions: discontinue immediately if rash, pruritus, or anaphylaxis occurs. Store at room temperature: keep in the original container, protect from moisture and heat.

Nitrofurantoin can interact with other medicines, affecting its absorption or toxicity.

Major Interactions (Avoid): - Antacids containing magnesium or aluminum: reduce nitrofurantoin absorption. - Probenecid: increases nitrofurantoin plasma levels, raising toxicity risk.

Moderate Interactions (Monitor Closely): - Warfarin: may enhance anticoagulant effect, requiring INR monitoring. - NSAIDs: combined use may increase risk of renal impairment. - Diuretics: can affect renal clearance of nitrofurantoin, necessitating renal function monitoring.