Nitrofurantoïne Prolepha (Nitrofurantoin)

Nitrofurantoin, the active ingredient in Nitrofurantoïne Prolepha, is a nitrofuran antibiotic presented as an oral dosage form for oral use. It treats uncomplicated urinary tract infections and is used for prophylaxis of recurrent infections in adults. GNH USA supplies Nitrofurantoïne Prolepha as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Nitrofurantoïne Prolepha is a nitrofuran antibiotic indicated for infections of the urinary tract. - Uncomplicated urinary tract infection (cystitis): eliminates the causative bacteria and resolves urinary symptoms. - Prophylaxis of recurrent urinary tract infections: reduces the frequency of future infection episodes. - Acute uncomplicated cystitis in women: provides bactericidal activity directly within the urinary tract.

Nitrofurantoin may cause a range of adverse reactions.

Common Side Effects: - Nausea: mild to moderate upset stomach. - Diarrhea: loose stools occurring during therapy. - Loss of appetite: reduced desire to eat. - Headache: transient mild headache.

Serious or Rare Side Effects: - Pulmonary toxicity: interstitial lung disease or acute respiratory distress. - Hepatic injury: elevated liver enzymes or hepatitis. - Severe allergic reactions: rash, Stevens‑Johnson syndrome, or anaphylaxis.

Before prescribing Nitrofurantoïne Prolepha, consider the following safety measures. - Renal function: assess creatinine clearance, as efficacy depends on urinary excretion. - Pregnancy: use only when benefit outweighs risk (Category B). - G6PD deficiency: avoid due to risk of hemolysis. - Drug interactions: review concomitant medications for absorption or toxicity concerns. - Store at ambient temperature: keep in the original container, protect from moisture and light.

Nitrofurantoin can interact with several medicines; monitoring is essential.

Major Interactions (Avoid): - Antacids containing magnesium or aluminum: reduce nitrofurantoin absorption; separate dosing by at least 2 hours. - Warfarin: may potentiate anticoagulant effect; monitor INR closely. - Fluoroquinolones: antagonistic antibacterial activity; avoid co‑administration.

Moderate Interactions (Monitor Closely): - Diuretics: may increase nitrofurantoin concentration; watch renal function. - Probenecid: decreases renal excretion, potentially raising plasma levels; adjust dose if needed.