Nitradisc (Glyceryl Trinitrate)

Glyceryl trinitrate, the active ingredient in Nitradisc, is an organic nitrate presented as a transdermal patch for transdermal use. It acts as a vasodilator that reduces myocardial oxygen demand and is indicated for the treatment and prophylaxis of angina pectoris in patients with chronic stable angina.

GNH USA supplies Nitradisc as a licensed, GDP‑compliant international pharmaceutical supplier, providing the product to hospitals, pharmacies and clinics worldwide while ensuring regulatory compliance, reliable logistics and strict quality standards for global distribution.

Nitradisc (glyceryl trinitrate) is used in the management of coronary artery disease, specifically for angina‑related conditions. - Angina pectoris: provides rapid relief of chest pain by dilating coronary vessels. - Prevention of angina attacks: maintains continuous nitrate delivery to reduce the frequency of episodes. - Chronic stable angina: improves exercise tolerance and reduces myocardial oxygen demand.

Adverse reactions to Nitradisc are generally related to its vasodilatory action and may vary in frequency and severity.

Common Side Effects: - Headache: throbbing pain often occurring shortly after patch application. - Flushing: warmth and redness of the skin, especially on the face and neck. - Dizziness: light‑headed sensation that may be posture‑related. - Hypotension: mild drop in blood pressure causing faintness.

Serious or Rare Side Effects: - Severe hypotension: marked blood pressure fall leading to syncope. - Reflex tachycardia: rapid heart rate in response to vasodilation. - Methemoglobinemia: elevated methemoglobin levels causing cyanosis. - Allergic skin reaction: rash, itching, or dermatitis at the patch site.

When prescribing Nitradisc, clinicians should consider several safety measures to minimise risks. - Cardiovascular assessment: evaluate baseline blood pressure and heart rate before initiating therapy. - Concomitant nitrates: avoid using with other nitrate preparations to prevent additive hypotension. - Phosphodiesterase‑5 inhibitors: do not combine with sildenafil or similar agents due to risk of severe hypotension. - Recent myocardial infarction: use with caution in patients who have had a recent heart attack. - Surgery or anesthesia: discontinue the patch prior to elective procedures to reduce intra‑operative hypotension. - Store at room temperature: keep below 25°C in the original pouch, protect from moisture and direct sunlight.

Nitradisc may interact with several medicines, altering its efficacy or safety profile.

Major Interactions (Avoid): - Other organic nitrates: combined use can cause profound hypotension. - Phosphodiesterase‑5 inhibitors (e.g., sildenafil): risk of severe blood pressure reduction. - Guanylate cyclase stimulators: additive vasodilatory effect leading to dangerous hypotension.

Moderate Interactions (Monitor Closely): - Antihypertensive agents (beta‑blockers, ACE inhibitors): may enhance blood pressure‑lowering effect. - Diuretics: can increase risk of orthostatic hypotension. - Alcohol: may potentiate vasodilatory side effects such as dizziness.