Nisegal (Dexamethasone, Ciprofloxacin)

Dexamethasone and Ciprofloxacin, the active ingredients in Nisegal, are a corticosteroid and a fluoroquinolone antibiotic presented as a topical ear preparation for auricular use. They treat inflammatory and bacterial ear conditions such as otitis externa in adults and children. GNH USA supplies Nisegal as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Nisegal combines a corticosteroid and a fluoroquinolone antibiotic to address inflammatory and bacterial processes in the ear.

- Otitis externa: reduces inflammation and eliminates the causative bacteria, relieving pain and discharge. - Ear canal inflammation: alleviates swelling, itching and discomfort associated with non‑infectious irritation. - Bacterial ear infections: eradicates susceptible organisms and improves hearing-related symptoms.

Common Side Effects: - Ear itching or mild burning sensation - Local irritation or redness of the ear canal - Transient hearing changes or muffled sound - Mild headache - Temporary tinnitus - Slight ear discharge

Serious or Rare Side Effects: - Allergic reaction including anaphylaxis - Severe ototoxicity with persistent hearing loss - Tympanic membrane perforation - Secondary fungal or bacterial infection - Systemic fluoroquinolone effects such as tendon rupture - Vision disturbances or photosensitivity

Before using Nisegal, consider the following precautions: - Assess for tympanic membrane perforation: avoid use if perforation is present. - Confirm bacterial etiology: reserve for confirmed or strongly suspected bacterial ear infections. - Hypersensitivity: do not use in patients with known allergy to corticosteroids or fluoroquinolones. - Monitor intra‑ocular pressure: caution in patients with glaucoma. - Pediatric use: observe for systemic absorption signs, especially with prolonged therapy. - Store at room temperature: keep in original container, protect from moisture and light.

Nisegal may interact with other medicines as follows:

Major Interactions (Avoid): - Systemic corticosteroids: increased risk of immunosuppression. - Systemic fluoroquinolones: heightened risk of tendon rupture. - Anticholinergic eye drops: may reduce local efficacy. - Live vaccines: possible reduced immune response. - NSAIDs: increased risk of ear bleeding.

Moderate Interactions (Monitor Closely): - Antacids containing aluminum or magnesium: may reduce ciprofloxacin absorption. - Warfarin: potential enhancement of anticoagulant effect. - Diuretics: possible electrolyte disturbances. - Oral contraceptives: may experience reduced effectiveness. - Diabetes medications: corticosteroid component may raise blood glucose levels.