GNH USA

Europe — EMA

Nirolex Febbre E Dolore (Paracetamol)

GNH USA supplies Nirolex Febbre E Dolore (Paracetamol), a analgesic/antipyretic for fever and mild to moderate pain. Request a quote for global supply.

Paracetamol

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1
Pack/s

What is Paracetamol?

Paracetamol, the active ingredient in Nirolex Febbre E Dolore, is an analgesic presented as a suppository for rectal use. It treats fever and mild to moderate pain in children and adults. GNH USA supplies Nirolex Febbre E Dolore as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

What is Paracetamol used for?

Paracetamol is an analgesic/antipyretic used to manage fever and mild to moderate pain. - Fever: reduces elevated body temperature - Headache: alleviates tension‑type headache - Musculoskeletal pain: eases minor muscle or joint discomfort - Dental pain: provides relief from toothache - Cold symptoms: helps relieve discomfort associated with common cold

What are the side effects of Paracetamol?

Paracetamol is generally well tolerated, but adverse reactions can occur.

Common Side Effects: - Skin rash: mild erythema or itching - Nausea: occasional upset stomach - Abdominal discomfort: mild pain or bloating - Local irritation: discomfort at the insertion site - Dizziness: transient light‑headedness

Serious or Rare Side Effects: - Anaphylaxis: severe allergic reaction requiring immediate medical attention - Stevens‑Johnson syndrome: rare severe skin disorder - Hepatotoxicity: liver injury, especially with overdose - Blood disorders: agranulocytosis or other hematologic abnormalities

What precautions apply to Paracetamol?

Paracetamol should be used with consideration of specific health factors. - Pregnancy: consult a healthcare professional as safety data are limited - Liver disease: use with caution; monitor hepatic function - Renal impairment: adjust use if recommended by prescriber - Concomitant alcohol: avoid excessive intake to reduce liver risk - Age: dosage for children should be determined by a healthcare provider - Store at room temperature: keep in original packaging, protect from moisture and heat

What does Paracetamol interact with?

Paracetamol may interact with other substances; awareness of major and moderate interactions is important.

Major Interactions (Avoid): - Alcohol: increased risk of liver injury - Other paracetamol‑containing products: risk of overdose - Warfarin: may enhance anticoagulant effect

Moderate Interactions (Monitor Closely): - Carbamazepine: may reduce paracetamol efficacy - Phenobarbital: may increase metabolism leading to lower effect

Frequently asked questions

What is Nirolex Febbre E Dolore used for?+
Nirolex Febbre E Dolore is a rectally administered paracetamol suppository indicated for the temporary relief of fever and mild to moderate pain, such as headache, muscle aches, dental discomfort, and symptoms associated with common colds.
How does paracetamol work to reduce fever and pain?+
Paracetamol reduces fever and pain by inhibiting the synthesis of prostaglandins in the central nervous system, primarily through weak cyclooxygenase (COX) inhibition. This action lowers the hypothalamic set‑point for temperature and raises the pain threshold, providing antipyretic and analgesic effects.
What is the usual dose of Nirolex Febbre E Dolore?+
The appropriate dose of Nirolex Febbre E Dolore is determined by a qualified prescriber based on the patient’s age, weight, and clinical condition. Healthcare professionals select the correct strength and frequency according to established guidelines and individual needs.
Is Nirolex Febbre E Dolore safe during pregnancy or breastfeeding?+
Safety of paracetamol suppositories during pregnancy or lactation should be evaluated by a healthcare professional. While paracetamol is commonly used when needed, the prescriber will consider the benefits and potential risks before recommending use in pregnant or breastfeeding individuals.
How do I order Nirolex Febbre E Dolore from GNH USA?+
To order, submit an enquiry on the product page at gnh-usa.com specifying the required quantity. GNH USA supplies hospitals, pharmacies and procurement teams worldwide, and will request verification of trade or institutional credentials before providing pricing, availability, shipping details and any necessary import documentation.
How does Nirolex Febbre E Dolore compare with ibuprofen?+
Both paracetamol (Nirolex Febbre E Dolore) and ibuprofen provide analgesic and antipyretic effects, but ibuprofen also has anti‑inflammatory activity. Paracetamol is generally gentler on the stomach and does not affect platelet function, whereas ibuprofen may cause gastrointestinal irritation and should be used with caution in certain cardiovascular conditions.
How should Nirolex Febbre E Dolore be stored?+
Store the suppositories at room temperature, preferably below 25 °C. Keep them in the original packaging to protect from moisture and direct heat, and ensure the container is tightly closed to maintain product integrity.
How is Nirolex Febbre E Dolore administered?+
The suppository is inserted rectally, preferably after a bowel movement. The patient should lie on their side with the lower leg drawn toward the abdomen, gently push the suppository into the rectum, and remain lying down for a few minutes to ensure proper absorption.
What are the most serious risks to watch for?+
Serious risks include severe allergic reactions such as anaphylaxis, rare skin conditions like Stevens‑Johnson syndrome, and potential liver toxicity, especially with overdose or chronic high‑dose use. Any signs of rash, jaundice, or unexplained fatigue should prompt immediate medical evaluation.
Who should not use Nirolex Febbre E Dolore?+
Individuals with known hypersensitivity to paracetamol or any component of the suppository should avoid use. Patients with severe liver disease, uncontrolled chronic alcoholism, or those taking other paracetamol‑containing products without medical supervision should also refrain from using this medication.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
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Product details

Drug
Paracetamol
Route
Rectal Use
Manufacturer
Almus S.R.L.
Origin
EU

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