GNH USA

Europe — EMA

Nimesulida Basi (Nimesulide)

GNH USA supplies Nimesulida Basi (Nimesulide), a nonsteroidal anti‑inflammatory drug for mild to moderate pain, osteoarthritis and dysmenorrhea.

Nimesulide

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What is Nimesulide?

Nimesulide, the active ingredient in Nimesulida Basi, is a nonsteroidal anti‑inflammatory drug (NSAID) presented as an oral formulation for oral use. It provides analgesic and anti‑inflammatory effects for mild to moderate pain and inflammatory conditions in adult patients, commonly prescribed for conditions such as osteoarthritis and dysmenorrhea.

GNH USA supplies Nimesulida Basi as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and offers reliable global distribution to meet the needs of healthcare providers.

What is Nimesulide used for?

Nimesulide is an NSAID that reduces inflammation and pain by selectively inhibiting cyclooxygenase‑2.

- Mild to moderate pain: provides analgesic relief for headache, dental pain, postoperative discomfort, and other acute pain states. - Osteoarthritis: decreases joint inflammation and improves functional mobility in patients with degenerative joint disease. - Dysmenorrhea: alleviates menstrual cramps by lowering uterine prostaglandin synthesis.

What are the side effects of Nimesulide?

Adverse reactions may vary in frequency and severity.

Common Side Effects: - Gastrointestinal discomfort: nausea, dyspepsia, or abdominal pain. - Headache: mild to moderate intensity. - Dizziness: transient episodes of light‑headedness. - Skin rash: mild erythema or pruritus.

Serious or Rare Side Effects: - Severe liver injury: elevated transaminases, hepatitis, or hepatic failure. - Severe skin reactions: Stevens‑Johnson syndrome or toxic epidermal necrolysis. - Anaphylaxis: acute allergic response with respiratory or circulatory compromise.

What precautions apply to Nimesulide?

Use of Nimesulida Basi requires careful assessment of patient risk factors. - Renal function: avoid or adjust dose in patients with severe renal impairment. - Hepatic function: monitor liver enzymes regularly; contraindicated in active liver disease. - Cardiovascular risk: use cautiously in individuals with a history of heart disease or thrombotic events. - Pregnancy and lactation: avoid unless benefits clearly outweigh potential risks; safety data are limited. - Concomitant NSAIDs or anticoagulants: increased risk of bleeding and gastrointestinal irritation. - Store at ambient temperature: keep below 25 °C, protect from moisture and light in the original packaging.

What does Nimesulide interact with?

Nimesulida Basi can interact with several drug classes; monitoring is advised.

Major Interactions (Avoid): - Other COX‑2 inhibitors: additive toxicity and increased risk of adverse hepatic effects. - Anticoagulants (e.g., warfarin, DOACs): heightened bleeding tendency. - Hepatotoxic agents (e.g., isoniazid, methotrexate): amplified risk of liver injury.

Moderate Interactions (Monitor Closely): - Concurrent NSAIDs or aspirin: greater gastrointestinal irritation. - Diuretics (e.g., furosemide): possible reduction in renal clearance of nimesulide. - Lithium: may increase serum lithium concentrations, requiring level checks.

Frequently asked questions

What conditions is Nimesulida Basi used for?+
Nimesulida Basi contains nimesulide, an NSAID indicated for mild to moderate pain, inflammatory joint disorders such as osteoarthritis, and primary dysmenorrhea. It is prescribed when a short‑term anti‑inflammatory and analgesic effect is needed in adult patients.
How does nimesulide work to relieve pain and inflammation?+
Nimesulide selectively blocks the cyclooxygenase‑2 (COX‑2) enzyme, reducing the synthesis of prostaglandins that mediate inflammation, pain, and fever. By sparing COX‑1 activity, it aims to maintain gastric protection while delivering its therapeutic effect.
What is the usual dose of Nimesulida Basi?+
The exact dosage of Nimesulida Basi is determined by the prescribing clinician based on the patient’s condition, age, renal and hepatic function, and other individual factors. Healthcare professionals follow local prescribing guidelines to set the appropriate regimen.
Is Nimesulida Basi safe to use during pregnancy or breastfeeding?+
Safety data for nimesulide in pregnancy and lactation are limited, and the product is generally avoided unless the potential benefit justifies the potential risk. Women who are pregnant, planning pregnancy, or breastfeeding should discuss alternatives with their healthcare provider.
How do I order Nimesulida Basi from GNH USA?+
To request Nimesulida Basi, submit an enquiry on the product page at gnh-usa.com, specifying the required quantity. GNH USA works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.
How does Nimesulida Basi compare with other NSAIDs?+
Nimesulide is a selective COX‑2 inhibitor, which may offer a lower risk of gastrointestinal irritation compared with non‑selective NSAIDs such as ibuprofen or diclofenac. However, it carries its own hepatic safety considerations, so clinicians balance efficacy, safety profile, and patient history when choosing therapy.
What are the storage requirements for Nimesulida Basi?+
Nimesulida Basi should be stored at ambient temperature, below 25 °C, in its original packaging. Protect the product from moisture, direct sunlight, and extreme temperatures to maintain its stability and potency throughout its shelf life.
How is Nimesulida Basi administered?+
The medication is taken orally, usually with a full glass of water. It can be taken with or without food, but patients should follow the prescribing clinician’s instructions regarding timing and whether to take it with meals to minimize gastrointestinal discomfort.
What are the most serious risks associated with Nimesulida Basi?+
The most serious adverse events include severe liver injury (hepatitis, hepatic failure) and rare but life‑threatening skin reactions such as Stevens‑Johnson syndrome or toxic epidermal necrolysis. Prompt medical attention is required if signs of liver dysfunction or severe skin rash develop.
Who should not use Nimesulida Basi?+
Patients with known hypersensitivity to nimesulide or other NSAIDs, active liver disease, severe renal impairment, or a history of serious cardiovascular events should avoid Nimesulida Basi. It is also contraindicated in individuals taking certain anticoagulants or other COX‑2 inhibitors without medical supervision.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
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Product details

Drug
Nimesulide
Route
Oral Use
Manufacturer
Laboratórios Basi – Indústria Farmacêutica, S.A.
Origin
EU

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