GNH USA

Europe — EMA

Nimesil (Nimesulide)

GNH USA supplies Nimesil (Nimesulide), a non‑steroidal anti‑inflammatory drug for acute pain, dysmenorrhea and inflammatory musculoskeletal conditions.

Nimesulide

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What is Nimesulide?

Nimesulide, the active ingredient in Nimesil, is a non‑steroidal anti‑inflammatory drug (NSAID) presented as a 100 mg oral granules for suspension (sachet) for oral use. It treats acute pain, dysmenorrhea, inflammatory musculoskeletal conditions and osteoarthritis in adult patients.\n\nGNH India supplies Nimesil as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

What is Nimesulide used for?

Nimesulide is an NSAID that reduces inflammation and pain by inhibiting cyclo‑oxygenase‑2.\n\nAcute pain: provides rapid analgesia for short‑term pain episodes.\nDysmenorrhea: relieves menstrual cramps and associated discomfort.\nInflammatory musculoskeletal conditions: decreases swelling and pain in sprains, strains or soft‑tissue injuries.\nOsteoarthritis: helps manage chronic joint pain and stiffness.

What are the side effects of Nimesulide?

Nimesulide may cause a range of adverse reactions.\n\nCommon Side Effects:\n- Nausea\n- Abdominal pain\n- Headache\n- Dizziness\n\nSerious or Rare Side Effects:\n- Hepatotoxicity (liver injury)\n- Severe allergic reactions, including anaphylaxis or skin rash\n- Gastrointestinal ulceration or bleeding\n- Blood disorders such as neutropenia or agranulocytosis

What precautions apply to Nimesulide?

Before prescribing Nimesil, consider the following safety measures.\n\nRenal function: assess kidney function prior to initiation.\nHepatic function: monitor liver enzymes during treatment.\nCardiovascular risk: use cautiously in patients with a history of heart disease.\nGastrointestinal risk: avoid in patients with active ulcer disease.\nPregnancy and lactation: contraindicated or only if benefits outweigh risks, as safety data are limited.\nStore at ambient temperature: keep below 25 °C, protect from moisture and direct light.

What does Nimesulide interact with?

Nimesulide can interact with several medicines; review patient medication lists.\n\nMajor Interactions (Avoid):\n- Anticoagulants (e.g., warfarin): increased bleeding risk.\n- Other NSAIDs or COX‑2 inhibitors: additive gastrointestinal toxicity.\n- Lithium: elevated serum lithium concentrations.\n\nModerate Interactions (Monitor Closely):\n- ACE inhibitors or ARBs: potential reduction in renal function.\n- SSRIs or SNRIs: heightened bleeding tendency.\n- Methotrexate: possible decreased clearance and toxicity.

Frequently asked questions

What is Nimesil used for?+
Nimesil contains the NSAID nimesulide and is prescribed to relieve acute pain, menstrual cramps (dysmenorrhea), inflammatory musculoskeletal conditions such as sprains or strains, and to manage chronic joint discomfort in osteoarthritis.
How does nimesulide work?+
Nimesulide works by selectively blocking the cyclo‑oxygenase‑2 (COX‑2) enzyme, which reduces the production of prostaglandins that cause inflammation, pain and fever. This targeted inhibition provides anti‑inflammatory and analgesic effects while sparing COX‑1 activity.
What is the usual dose of Nimesil?+
The exact dose of Nimesil is determined by the prescribing clinician based on the patient’s condition, age and response. Typically, an adult may be instructed to take one 100 mg sachet a few times daily for a short‑term period, but the prescriber sets the final regimen.
Is Nimesil safe in pregnancy or breastfeeding?+
Safety data for nimesulide during pregnancy and lactation are limited, and the product is generally avoided unless the potential benefit justifies the risk. Women who are pregnant, planning pregnancy, or breastfeeding should discuss alternative therapies with their healthcare provider.
How do I order Nimesil from GNH USA?+
To request Nimesil, submit an enquiry on the product page at gnh-usa.com indicating the required quantity. GNH USA works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.
How does Nimesil compare with other NSAIDs?+
Nimesil (nimesulide) is a COX‑2‑selective NSAID, which may offer a lower risk of gastrointestinal irritation compared with non‑selective NSAIDs such as ibuprofen or diclofenac. However, it carries its own safety profile, including rare liver toxicity, and should be chosen based on individual patient risk factors.
How should Nimesil be stored and handled?+
Store Nimesil sachets at ambient temperature, preferably below 25 °C, in their original packaging to protect from moisture and direct light. Keep out of reach of children and do not use if the package is damaged or the product appears discoloured.
How is Nimesil administered?+
Nimesil is supplied as oral granules for suspension. The contents of one sachet are mixed with a measured amount of water (usually 50 ml) to form a uniform suspension, which is then taken orally as directed by the prescriber.
What are the most serious risks to watch for while taking Nimesil?+
Serious adverse events include liver injury (hepatotoxicity), severe allergic reactions such as anaphylaxis or skin eruptions, gastrointestinal ulceration or bleeding, and blood disorders like neutropenia. Patients should seek immediate medical attention if they notice jaundice, rash, severe abdominal pain or unexplained bruising.
Who should not use Nimesil?+
Nimesil should be avoided in patients with known hypersensitivity to nimesulide or other NSAIDs, active peptic ulcer disease, severe liver or kidney impairment, uncontrolled heart failure, and in those who are pregnant or breastfeeding unless clearly indicated by a physician.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
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Product details

Drug
Nimesulide
Route
Oral Use
Manufacturer
Laboratori Guidotti S.P.A.
Origin
EU

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