GNH USA

Europe — EMA

Nimefort (Nimesulide)

GNH USA supplies Nimefort (Nimesulide), a nonsteroidal anti-inflammatory drug for mild to moderate pain, fever and osteoarthritis.

Nimesulide

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What is Nimesulide?

Nimesulide, the active ingredient in Nimefort, is a nonsteroidal anti-inflammatory drug (NSAID) presented as an oral tablet for oral use. It is used to relieve mild to moderate pain, fever, osteoarthritis and dysmenorrhea in adults.

GNH USA supplies Nimefort as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

What is Nimesulide used for?

Nimesulide is indicated for conditions involving pain, inflammation, or fever.

Mild to moderate pain: provides analgesic relief in adults Fever: reduces elevated body temperature Osteoarthritis: alleviates joint pain and inflammation Dysmenorrhea: eases menstrual cramps

What are the side effects of Nimesulide?

Nimesulide may cause a range of adverse reactions, most of which are dose‑related and reversible.

Common Side Effects: - Gastrointestinal discomfort: mild stomach pain or indigestion. - Nausea: feeling of queasiness. - Headache: mild to moderate head pain. - Dizziness: transient light‑headedness.

Serious or Rare Side Effects: - Hepatotoxicity: liver enzyme elevation or injury. - Severe skin reactions: such as Stevens‑Johnson syndrome. - Renal impairment: reduced kidney function.

What precautions apply to Nimesulide?

Before prescribing Nimefort, clinicians should consider several safety measures.

Assess liver function: baseline tests are recommended before initiating therapy. Avoid in patients with known NSAID hypersensitivity: risk of allergic reactions. Use caution in the elderly: higher susceptibility to gastrointestinal bleeding. Limit duration: employ the lowest effective dose for the shortest necessary period. Avoid concomitant anticoagulants: increased bleeding risk. Store at ambient temperature: keep in the original pack, protect from moisture.

What does Nimesulide interact with?

Nimefort can interact with other medicines, requiring careful review.

Major Interactions (Avoid): - Concurrent use with other COX‑2 inhibitors: increased toxicity. - Combined with anticoagulants (warfarin, heparin): heightened bleeding risk. - Co‑administration with hepatotoxic drugs (e.g., isoniazid): risk of liver injury.

Moderate Interactions (Monitor Closely): - Concurrent use with diuretics or ACE inhibitors: may affect renal function. - Combination with corticosteroids: increased gastrointestinal ulcer risk. - Use with lithium: possible increase in lithium serum levels.

Frequently asked questions

What is Nimefort used for?+
Nimefort contains nimesulide, an NSAID indicated for relief of mild to moderate pain, reduction of fever, management of osteoarthritis symptoms, and treatment of dysmenorrhea in adults. It works by targeting inflammation pathways to provide analgesic and antipyretic effects.
How does nimesulide work?+
Nimesulide selectively inhibits cyclooxygenase‑2 (COX‑2), the enzyme responsible for converting arachidonic acid into prostaglandins that mediate pain, inflammation and fever. By reducing prostaglandin synthesis, it provides analgesic, antipyretic and anti‑inflammatory effects while sparing COX‑1 activity, which helps limit gastrointestinal side effects compared with non‑selective NSAIDs.
What is the usual dose of Nimefort?+
The specific dose of Nimefort is determined by the prescribing healthcare professional based on the patient’s condition, age, weight and response. Prescribers follow local guidelines and product labeling to select the appropriate strength and dosing interval, and patients should follow the instructions provided on the prescription label.
Is Nimefort safe during pregnancy or breastfeeding?+
The safety of nimesulide in pregnancy and lactation has not been established, and it is generally contraindicated during the third trimester because of potential fetal risks. Women who are pregnant, planning pregnancy, or breastfeeding should discuss alternative therapies with their healthcare provider before using Nimefort.
How do I order Nimefort from GNH USA?+
To place an order, submit an inquiry on the product page at gnh-usa.com specifying the desired quantity of Nimefort. GNH USA works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any required cold‑chain or temperature control) and assistance with import documentation.
How does Nimefort compare with other NSAIDs?+
Nimefort (nimesulide) is a COX‑2‑selective NSAID, which may offer a lower risk of gastrointestinal irritation compared with non‑selective NSAIDs such as ibuprofen or diclofenac. However, it carries its own safety considerations, including potential liver toxicity, and its efficacy in pain and inflammation is comparable to other agents in the same therapeutic class.
How should Nimefort be stored?+
Nimefort should be stored at ambient temperature, below 25 °C, in its original packaging to protect it from moisture and light. Keep the product out of reach of children and do not use it after the expiration date printed on the label.
How is Nimefort administered?+
Nimefort is taken orally, usually with a full glass of water. It may be taken with or without food, but taking it with food can help reduce possible stomach discomfort. Patients should swallow the tablet whole and not split, crush or chew it unless directed by a healthcare professional.
What are the most serious risks associated with Nimefort?+
The most serious risks include hepatotoxicity, which can manifest as elevated liver enzymes or liver failure, and severe skin reactions such as Stevens‑Johnson syndrome or toxic epidermal necrolysis. Additionally, rare cases of renal impairment and serious gastrointestinal bleeding have been reported, especially when used with other NSAIDs or anticoagulants.
Who should not use Nimefort?+
Nimefort should be avoided in individuals with known hypersensitivity to nimesulide or other NSAIDs, in patients with active peptic ulcer disease, severe liver or kidney impairment, and in those taking anticoagulants without medical supervision. It is also contraindicated during the third trimester of pregnancy and in children under the age specified in local labeling.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
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Product details

Drug
Nimesulide
Route
Oral Use
Manufacturer
Solinea Sp. Z O.O. Sp. K.
Origin
EU

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