Nilstat (Nystatin)

Nystatin, the active ingredient in Nilstat, is a polyene antifungal presented as an oral suspension for oral use. It treats candidiasis of the gastrointestinal tract and oral cavity in patients of various ages.

GNH USA supplies Nilstat as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Nystatin is used to treat fungal infections of the gastrointestinal and oral mucosa.

- Gastrointestinal candidiasis: reduces fungal load and relieves symptoms in the GI tract. - Oral candidiasis (thrush): clears yeast overgrowth and improves oral comfort. - Infant candidiasis: helps eradicate Candida infections in newborns and young children.

Nystatin may cause a range of adverse reactions, most of which are mild and reversible.

Common Side Effects: - Nausea: mild stomach upset after oral administration. - Vomiting: occasional expulsion of the suspension. - Abdominal discomfort: cramps or pain in the stomach area. - Diarrhea: loose stools during treatment. - Altered taste: temporary metallic or bitter sensation. - Mild skin rash: localized itching or redness.

Serious or Rare Side Effects: - Anaphylactic reaction: severe allergic response requiring immediate medical attention. - Hepatic dysfunction: signs of liver injury such as jaundice. - Neutropenia: marked reduction in white blood cells. - Stevens‑Johnson syndrome: severe skin blistering and detachment. - Renal impairment: decreased kidney function. - Eosinophilia: elevated eosinophil count indicating hypersensitivity.

Before prescribing Nilstat, clinicians should consider several safety aspects.

- Assess renal function: adjust use in patients with severe renal impairment. - Monitor hepatic function: rare liver toxicity has been reported. - Avoid in patients with known hypersensitivity to nystatin or other polyene antifungals. - Use with caution in immunocompromised individuals: risk of systemic infection. - Store at below 25°C: keep in the original container, protect from moisture and light.

Nystatin may interact with other medicines; some combinations require avoidance while others need monitoring.

Major Interactions (Avoid): - Concurrent use of nephrotoxic drugs: may increase risk of renal toxicity. - Co‑administration with systemic azoles: may alter fungal flora and reduce efficacy. - Use with cholestyramine: can bind nystatin and reduce absorption.

Moderate Interactions (Monitor Closely): - Antacids containing aluminum or magnesium: may affect oral suspension pH. - Probiotic supplements: may interfere with colonization of Candida. - High‑fat meals: may delay gastric emptying and affect drug contact time.