Nikofrenon (Nicotine)

Nicotine, the active ingredient in Nikofrenon, is a nicotinic receptor agonist presented as a transdermal patch for transdermal use. It treats nicotine dependence and aids smoking cessation in adult smokers seeking to quit.

GNH USA supplies Nikofrenon as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to EU GMP standards and provides reliable, on‑time delivery across multiple regions. We also offer technical assistance for optimal patch application.

Nikofrenon is indicated for nicotine dependence and supports smoking cessation therapy.

- Smoking cessation: helps adult smokers reduce withdrawal symptoms and achieve abstinence. - Nicotine dependence: provides controlled nicotine delivery to manage cravings during quit attempts. - Relapse prevention: supports individuals who have recently quit to maintain tobacco‑free status. - Adjunct to behavioral counseling: enhances the effectiveness of counseling programs. - Use in combination therapy: can be combined with other nicotine replacement forms for step‑down approaches.

Common Side Effects: - Skin irritation at the application site: redness, itching, or mild rash. - Sleep disturbance: difficulty falling asleep or staying asleep. - Vivid dreams or unusual dreaming patterns. - Nausea or mild gastrointestinal upset. - Headache. - Dizziness.

Serious or Rare Side Effects: - Allergic reaction: swelling, hives, or severe rash. - Severe skin necrosis or ulceration at the patch site. - Hypotension or marked drop in blood pressure. - Tachycardia or rapid heart rate. - Syncope (fainting) episodes. - Persistent or worsening chest pain.

Before using Nikofrenon, consider the following precautions: - Assess cardiovascular status: nicotine can increase heart rate and blood pressure. - Avoid use in recent myocardial infarction: risk of cardiac events. - Do not use in uncontrolled hypertension: monitor blood pressure regularly. - Pregnancy and lactation: consult a healthcare professional before initiating therapy. - Apply to clean, dry, hairless skin and rotate sites to minimize skin irritation. - Store at room temperature: keep in the original packaging, protect from moisture and heat.

Nikofrenon may interact with several drug classes. Review the following interactions:

Major Interactions (Avoid): - Monoamine oxidase inhibitors (MAOIs): increased risk of hypertensive crisis. - Beta‑blockers: nicotine‑induced tachycardia may be masked. - Insulin or oral hypoglycemics: nicotine can affect glucose control.

Moderate Interactions (Monitor Closely): - CYP2A6 inhibitors (e.g., methoxsalen): may raise nicotine plasma levels. - Antidepressants (SSRIs): possible alteration of nicotine metabolism. - Alcohol: may enhance nicotine's cardiovascular effects.