GNH USA

Europe — EMA

Nifuroksazyd Polfarmex (Nifuroxazide)

GNH USA supplies Nifuroksazyd Polfarmex (Nifuroxazide), a nitrofuran antibacterial for acute infectious diarrhoea and intestinal bacterial infections.

Nifuroxazide

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What is Nifuroxazide?

Nifuroxazide, the active ingredient in Nifuroksazyd Polfarmex, is a nitrofuran antibacterial presented as an oral formulation for oral use. It acts locally in the gastrointestinal tract to treat acute infectious diarrhoea and other intestinal bacterial infections in adults and children.

GNH USA supplies Nifuroksazyd Polfarmex as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

What is Nifuroxazide used for?

Nifuroksazyd Polfarmex is a nitrofuran antibacterial used to manage infections of the gastrointestinal tract. - Acute infectious diarrhoea: reduces the duration and severity of diarrhoeal episodes caused by susceptible bacteria. - Intestinal bacterial infections: eradicates pathogenic bacteria colonising the gut, helping restore normal flora. - Bacterial enteritis: alleviates symptoms and limits bacterial proliferation in the intestines.

What are the side effects of Nifuroxazide?

Nifuroksazyd Polfarmex may cause adverse reactions, most of which are mild and reversible.

Common Side Effects: - Nausea: mild stomach upset reported by some patients. - Abdominal cramps: transient discomfort during treatment. - Flatulence: increased intestinal gas. - Taste alteration: temporary change in taste perception. - Skin rash: mild erythema or itching.

Serious or Rare Side Effects: - Severe allergic reaction: anaphylaxis or angioedema requiring immediate medical attention. - Hepatotoxicity: signs of liver injury such as jaundice or elevated enzymes. - Hematologic abnormalities: rare cases of neutropenia or thrombocytopenia. - Clostridioides difficile infection: overgrowth due to alteration of gut flora. - Persistent diarrhoea: worsening of symptoms despite therapy.

What precautions apply to Nifuroxazide?

Before prescribing Nifuroksazyd Polfarmex, consider the following safety measures. - Pregnancy: avoid use unless clearly needed; safety data are limited. - Breastfeeding: discontinue if infant shows signs of gastrointestinal disturbance. - Renal impairment: monitor for accumulation of metabolites in severe dysfunction. - Known hypersensitivity: do not administer to patients with previous nitrofuran allergy. - Store at ambient temperature: keep below 25 °C, in the original container, protected from moisture and direct sunlight.

What does Nifuroxazide interact with?

Nifuroksazyd Polfarmex can interact with other medicines; awareness of the interaction level helps guide therapy.

Major Interactions (Avoid): - Anticoagulants (e.g., warfarin): may increase bleeding risk. - Other nitrofuran agents: additive toxicity.

Moderate Interactions (Monitor Closely): - Oral contraceptives: possible reduction in efficacy. - Probiotics: may alter gut flora and affect drug activity. - Antacids containing aluminum or magnesium: could affect drug dissolution.

Frequently asked questions

What is Nifuroksazyd Polfarmex used for?+
Nifuroksazyd Polfarmex contains nifuroxazide, an oral nitrofuran antibacterial indicated for the treatment of acute infectious diarrhoea and other intestinal bacterial infections. It works locally in the gut to eliminate susceptible pathogens and reduce diarrhoeal symptoms.
How does nifuroxazide work in the body?+
After oral ingestion, nifuroxazide remains largely within the gastrointestinal tract. Bacterial enzymes reduce it to reactive metabolites that damage bacterial DNA and inhibit protein synthesis, leading to bacterial cell death while minimizing systemic absorption.
What is the usual dose of Nifuroksazyd Polfarmex?+
The dosage regimen for Nifuroksazyd Polfarmex is determined by the prescribing healthcare professional based on the patient’s age, weight, severity of infection, and local treatment guidelines. Patients should follow the prescriber’s instructions precisely.
Is Nifuroksazyd Polfarmex safe during pregnancy or breastfeeding?+
Safety data for nifuroxazide in pregnancy and lactation are limited. It should only be used if the potential benefit justifies any possible risk to the fetus or infant, and the decision must be made by a qualified healthcare provider.
How do I order Nifuroksazyd Polfarmex from GNH USA?+
To place an order, submit an enquiry on the product page at gnh-usa.com, specifying the required quantity. GNH USA works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.
How does Nifuroksazyd Polfarmex compare with other intestinal antibiotics?+
Nifuroksazyd Polfarmex offers a locally acting nitrofuran mechanism, which differs from systemic antibiotics such as fluoroquinolones or macrolides. Its limited absorption reduces systemic side effects, making it suitable for uncomplicated bacterial diarrhoea, whereas broader‑spectrum agents may be reserved for severe or invasive infections.
What are the storage requirements for Nifuroksazyd Polfarmex?+
Store the product at ambient temperature, preferably below 25 °C. Keep it in the original packaging, protect it from moisture, direct sunlight and extreme heat to maintain stability and potency.
How is Nifuroksazyd Polfarmex administered?+
The medication is taken orally, usually with water. It is formulated to act locally in the gastrointestinal tract, so it should be swallowed whole and not crushed or dissolved unless specifically instructed by a healthcare professional.
What are the most serious risks associated with Nifuroksazyd Polfarmex?+
Serious adverse reactions, though rare, include severe allergic responses such as anaphylaxis, hepatotoxicity, hematologic abnormalities like neutropenia, and the potential for Clostridioides difficile infection. Patients should seek immediate medical attention if they experience symptoms such as rash, swelling, jaundice, or persistent diarrhoea.
Who should not use Nifuroksazyd Polfarmex?+
Individuals with a known hypersensitivity to nifuroxazide or other nitrofuran compounds should avoid this medication. It is also contraindicated in patients where the risk outweighs the benefit, such as those with severe liver disease, unless specifically directed by a physician.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
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Product details

Drug
Nifuroxazide
Route
Oral Use
Manufacturer
Polfarmex S.A.
Origin
EU

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