Niflugel (Niflumic Acid)

Niflumic Acid, the active ingredient in Niflugel, is a fenamate (non‑steroidal anti‑inflammatory drug) presented as a topical gel for local anti‑inflammatory use. The preparation is intended for external application to skin or ocular surfaces, where it helps to reduce prostaglandin‑mediated pain, swelling and erythema in musculoskeletal and eye‑related inflammatory conditions.

GNH USA supplies Niflugel as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, providing reliable sourcing for regulated markets across Europe, Asia, the Americas and the Middle East.

Niflugel, a topical NSAID, is employed to manage inflammatory conditions of the musculoskeletal and ocular systems. - Musculoskeletal pain: provides local relief of pain and inflammation in muscles, tendons and joints. - Tendinitis: reduces swelling and discomfort associated with inflamed tendons. - Bursitis: alleviates inflammation of bursae surrounding joints. - Allergic conjunctivitis: helps relieve ocular redness, itching and swelling caused by allergic reactions.

Topical application of Niflugel may be associated with local and systemic adverse reactions.

Common Side Effects: - Skin irritation: mild redness or itching at the application site. - Burning sensation: transient warmth or stinging when first applied. - Dryness: localized skin dryness or flaking. - Pruritus: itching that may develop after repeated use.

Serious or Rare Side Effects: - Contact dermatitis: severe allergic skin reaction with swelling and vesicles. - Systemic NSAID effects: rare gastrointestinal ulceration or bleeding. - Renal impairment: unlikely but possible in susceptible individuals. - Anaphylaxis: life‑threatening allergic response requiring immediate medical attention.

When using Niflugel, certain precautions should be observed to minimize risks. - Allergy assessment: confirm no known hypersensitivity to fenamates or other NSAIDs. - Application area: limit use to intact skin or ocular surface; avoid broken skin or mucosa. - Concomitant NSAIDs: avoid simultaneous use of systemic NSAIDs to reduce cumulative toxicity. - Pregnancy and lactation: use only if clearly indicated after risk‑benefit evaluation by a healthcare professional. - Age considerations: exercise caution in pediatric and elderly patients due to altered skin absorption. - Store at room temperature: keep below 25 °C in the original container, protect from moisture and direct sunlight.

Niflugel can interact with other medicines; awareness of these interactions helps ensure safe use.

Major Interactions (Avoid): - Systemic NSAIDs: combined use may increase risk of gastrointestinal bleeding and renal toxicity. - Anticoagulants/antiplatelet agents: heightened potential for bleeding complications. - Corticosteroids: additive risk of skin thinning and delayed wound healing.

Moderate Interactions (Monitor Closely): - Lithium: NSAIDs may raise lithium serum levels, requiring monitoring. - Methotrexate: concurrent NSAIDs can reduce renal clearance of methotrexate. - Diuretics: possible reduction in renal perfusion, necessitating renal function checks.