Niflugel (Niflumic Acid)

Niflumic Acid, the active ingredient in Niflugel, is a fenamate (NSAID) presented as a topical gel for topical use. It provides anti‑inflammatory and analgesic effects for musculoskeletal discomfort in adults.

GNH USA supplies Niflugel as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Niflugel, a topical fenamate NSAID, is applied to conditions involving inflammation and pain in the musculoskeletal system.

Musculoskeletal pain: reduces localized pain and swelling in muscles and joints. Rheumatoid arthritis flare: alleviates joint inflammation and discomfort when applied to affected areas. Osteoarthritis of the knee: provides topical relief of pain and stiffness associated with degenerative joint disease.

Topical application of Niflugel may cause local and systemic adverse reactions.

Common Side Effects: - Skin irritation: redness, burning, or stinging at the application site. - Itching or pruritus. - Dryness or peeling of the skin. - Contact dermatitis. - Mild erythema. - Localized swelling.

Serious or Rare Side Effects: - Systemic gastrointestinal ulceration or bleeding. - Renal impairment, especially with extensive use. - Severe hypersensitivity reactions such as Stevens‑Johnson syndrome. - Anaphylactic shock. - Hepatotoxicity. - Blood dyscrasias (e.g., agranulocytosis).

When using Niflugel, consider the following safety measures.

Avoid use on broken or infected skin: may increase systemic absorption. Do not apply near eyes or mucous membranes: risk of irritation. Limit duration to the period prescribed by a healthcare professional. Concurrent systemic NSAIDs: discuss with a physician to avoid additive toxicity. Pregnancy and lactation: use only if clearly indicated and under medical supervision. Store at room temperature: keep in the original container, protect from moisture and light.

Niflugel can interact with other medicines, requiring attention to avoid adverse outcomes.

Major Interactions (Avoid): - Systemic NSAIDs: increased risk of gastrointestinal bleeding. - Anticoagulants (e.g., warfarin, DOACs): heightened bleeding tendency.

Moderate Interactions (Monitor Closely): - Diuretics: may affect renal function when combined with NSAIDs. - ACE inhibitors or ARBs: monitor renal parameters. - Lithium: potential increase in lithium serum levels. - Corticosteroids: additive risk of skin thinning and ulceration.