Nifelat R (Nifedipine)

Nifedipine, the active ingredient in Nifelat R, is a calcium channel blocker presented as an oral dosage form for oral use. It treats hypertension and angina pectoris in adult patients.\n\nGNH India supplies Nifelat R as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Nifelat R belongs to the calcium channel blocker class and is used in cardiovascular conditions where vascular tone needs to be reduced.\n\nHypertension: lowers systemic blood pressure by relaxing arterial smooth muscle.\nAngina pectoris: reduces frequency and severity of chest pain by improving coronary blood flow.

Nifedipine may cause a range of adverse reactions that vary in frequency and severity.\n\nCommon Side Effects:\n- Headache\n- Flushing\n- Peripheral edema\n- Dizziness\n\nSerious or Rare Side Effects:\n- Severe hypotension\n- Myocardial infarction\n- Hepatic dysfunction or jaundice

Before prescribing Nifelat R, clinicians should consider several safety measures.\n\nMonitor blood pressure regularly: ensure therapeutic effect without excessive drop.\nAvoid abrupt discontinuation: taper to prevent rebound hypertension.\nUse caution in hepatic impairment: metabolism is hepatic, dose may need adjustment.\nUse caution in patients with heart failure: risk of worsening symptoms.\nUse caution in elderly patients: increased sensitivity to hypotensive effects.\nStore at room temperature: keep in original container, protect from moisture and direct sunlight.

Nifedipine can interact with several medicines, altering its efficacy or safety.\n\nMajor Interactions (Avoid):\n- Strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole): may cause toxic levels.\n- Grapefruit juice: increases plasma concentration, raising risk of hypotension.\n- High‑dose simvastatin (>20 mg): risk of rhabdomyolysis.\n\nModerate Interactions (Monitor Closely):\n- Beta‑blockers: additive heart rate reduction.\n- Diuretics: may enhance blood pressure lowering.\n- Digoxin: increased serum digoxin levels, monitor for toxicity.