Nifelat (Nifedipine)

Nifedipine, the active ingredient in Nifelat, is a calcium channel blocker presented as an oral tablet for systemic use. It is employed to lower high blood pressure, relieve chest pain from angina, and improve blood flow in Raynaud's phenomenon, primarily in adult patients.

GNH USA supplies Nifelat as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides reliable sourcing for regulated markets. Its distribution network ensures timely delivery across Europe, Asia, Africa and the Americas.

Nifedipine is a dihydropyridine calcium channel blocker used to manage vascular and cardiac conditions. - Hypertension: reduces peripheral resistance and lowers blood pressure. - Angina pectoris: improves coronary blood flow and relieves chest pain. - Raynaud's phenomenon: alleviates vasospasm and enhances peripheral circulation.

Nifedipine may cause a range of adverse reactions, varying from mild to serious. Common Side Effects: - Headache: mild to moderate headache often after the first dose. - Flushing: transient warmth and redness of the skin. - Peripheral edema: swelling of the ankles or lower legs. Serious or Rare Side Effects: - Hypotension: marked drop in blood pressure that may cause fainting. - Reflex tachycardia: rapid heart rate in response to vasodilation. - Severe allergic reaction: rash, itching, swelling, or difficulty breathing.

When prescribing Nifedipine, clinicians should consider several precautionary measures to ensure safe use. - Blood pressure monitoring: check baseline and periodic readings to avoid excessive hypotension. - Concomitant cardiac disease: use cautiously in patients with severe aortic stenosis or heart failure. - Grapefruit products: avoid because they can increase nifedipine plasma levels. - Liver impairment: dose adjustment may be required in moderate to severe hepatic dysfunction. - Pregnancy and lactation: use only if clearly needed; risk to fetus is not well established. - Store at ambient temperature: keep below 25°C in the original container, protect from moisture and light.

Nifedipine can interact with several medicines, altering its effectiveness or safety profile. Major Interactions (Avoid): - Strong CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin): may cause dangerous accumulation. - Simultaneous use with other potent vasodilators (e.g., nitroglycerin): risk of severe hypotension. Moderate Interactions (Monitor Closely): - CYP3A4 inducers (e.g., rifampin, carbamazepine): may reduce therapeutic effect. - Beta‑blockers: may blunt compensatory heart rate increase. - Diuretics: may enhance orthostatic hypotension.