Nifedipine Retard Eg

Nifedipine, the active ingredient in Nifedipine Retard Eg, is a calcium channel blocker presented as an extended‑release tablet for oral use. It is employed to lower high blood pressure and to relieve chest pain caused by chronic stable angina in adult patients.

GNH USA supplies Nifedipine Retard Eg as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, with sourcing from the European Union market. The company adheres to stringent quality standards and provides regulatory documentation to facilitate import and distribution.

Nifedipine is used in cardiovascular therapy to manage conditions related to elevated vascular resistance and myocardial oxygen demand. Hypertension: Reduces systemic blood pressure by dilating peripheral arteries. Chronic stable angina: Improves exercise tolerance and decreases frequency of chest pain episodes. Coronary artery disease symptom control: Alleviates ischemic symptoms by decreasing cardiac workload.

Nifedipine may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects: - Headache: mild to moderate headache often occurring early in therapy. - Flushing: transient warmth and redness of the face or neck. - Peripheral edema: swelling of ankles or lower legs due to fluid accumulation. - Dizziness or light‑headedness: especially upon standing.

Serious or Rare Side Effects: - Severe hypotension: marked drop in blood pressure leading to fainting. - Cardiac arrhythmias: irregular heart rhythms, particularly in patients with pre‑existing conduction disorders. - Hepatic dysfunction: elevated liver enzymes or jaundice.

When prescribing Nifedipine, clinicians should consider several precautionary measures to ensure safe use. - Assess cardiovascular status: evaluate blood pressure and heart rate before initiating therapy. - Review concomitant medications: avoid drugs that may potentiate hypotensive effects. - Monitor in hepatic impairment: dose adjustment may be required in patients with liver dysfunction. - Caution in elderly patients: start with lower doses and observe for orthostatic symptoms. - Store at ambient temperature: keep tablets below 25 °C in the original container, protected from moisture.

Nifedipine can interact with other medicines, altering its efficacy or safety profile.

Major Interactions (Avoid): - Strong CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin): can markedly increase nifedipine plasma levels, raising risk of severe hypotension. - Grapefruit juice: potent CYP3A4 inhibition may lead to excessive drug accumulation and adverse events.

Moderate Interactions (Monitor Closely): - Beta‑blockers: combined use may cause additive bradycardia or heart block; monitor heart rate. - Diuretics: concurrent therapy may enhance hypotensive effect; adjust dose as needed. - Other calcium channel blockers: additive vasodilatory effects may increase risk of edema; observe patient response.