Nifedipine Retard Cf

Nifedipine, the active ingredient in Nifedipine Retard Cf, is a calcium channel blocker presented as an oral dosage form for oral use. It is used to manage hypertension and angina pectoris in adult patients.

GNH USA supplies Nifedipine Retard Cf as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Nifedipine is indicated for several cardiovascular conditions that involve abnormal vascular tone or myocardial oxygen demand.

- Hypertension: lowers systemic blood pressure by dilating peripheral arteries. - Angina pectoris: reduces frequency and severity of chest pain by improving coronary blood flow. - Raynaud's phenomenon: alleviates vasospastic attacks in peripheral extremities.

Nifedipine may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects: - Headache: mild to moderate intensity. - Flushing: transient warmth and redness of the skin. - Peripheral edema: swelling of the ankles or feet. - Dizziness or light‑headedness. - Nausea or abdominal discomfort. - Palpitations or tachycardia.

Serious or Rare Side Effects: - Severe hypotension: marked drop in blood pressure. - Myocardial infarction: especially in patients with existing coronary artery disease. - Bradycardia: dangerously slow heart rate. - Hepatic dysfunction: elevated liver enzymes or hepatitis. - Allergic reactions: rash, pruritus, or anaphylaxis. - Stevens‑Johnson syndrome or toxic epidermal necrolysis.

When prescribing Nifedipine, clinicians should consider several precautionary measures to ensure patient safety.

- Blood pressure monitoring: check regularly after initiation or dose changes. - Cardiac assessment: evaluate for heart failure or severe aortic stenosis before use. - Hepatic impairment: use with caution in patients with liver disease. - Abrupt discontinuation: avoid sudden stop to prevent rebound hypertension. - Concomitant drugs: review other medications that may affect blood pressure or heart rate. - Store at room temperature: keep in the original container, protect from moisture and direct sunlight.

Nifedipine can interact with other medicines, altering its effectiveness or increasing the risk of adverse events.

Major Interactions (Avoid): - Strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole): may increase nifedipine plasma levels. - Grapefruit juice: can markedly raise drug concentration. - Beta‑blockers: combined use may cause profound hypotension.

Moderate Interactions (Monitor Closely):\n- Digoxin: nifedipine may raise digoxin levels, requiring monitoring. - Rifampicin or other CYP3A4 inducers: may reduce nifedipine efficacy. - Diuretics: concurrent use may enhance hypotensive effect.