Nifedipin T Retard Al (Nifedipine)

Nifedipine, the active ingredient in Nifedipin T Retard Al, is a calcium channel blocker presented as an oral tablet for oral use. It is employed to lower high blood pressure and to relieve chest pain caused by reduced blood flow to the heart in adult patients.

GNH USA supplies Nifedipin T Retard Al as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Nifedipine acts on the vascular smooth‑muscle calcium channels to manage cardiovascular conditions. - Hypertension: lowers systemic blood pressure by relaxing arterial smooth muscle. - Chronic stable angina: reduces myocardial oxygen demand and improves exercise tolerance. - Coronary artery disease: helps prevent ischemic episodes by enhancing coronary blood flow.

Nifedipine may cause a range of adverse reactions, from mild to serious.

Common Side Effects: - Headache: mild to moderate pressure sensation. - Flushing: transient warmth and redness of the skin. - Peripheral edema: swelling of ankles or feet. - Dizziness or light‑headedness, especially on standing. - Tachycardia: increased heart rate. - Nausea or abdominal discomfort.

Serious or Rare Side Effects: - Severe hypotension leading to fainting. - Myocardial infarction or worsening angina. - Life‑threatening arrhythmias. - Hepatic dysfunction or jaundice. - Severe allergic reactions such as Stevens‑Johnson syndrome.

Before initiating therapy with nifedipine, consider the following safety measures. - Blood pressure monitoring: regularly check to avoid excessive hypotension. - Cardiac assessment: evaluate for recent myocardial infarction or unstable angina. - Hepatic function: use cautiously in patients with liver impairment. - Concomitant antihypertensives: adjust doses to prevent additive blood‑pressure lowering. - Discontinuation: avoid abrupt cessation to reduce rebound hypertension risk. - Store at room temperature: keep in the original container, protect from moisture and direct sunlight.

Nifedipine can interact with several medicines, altering its efficacy or safety profile.

Major Interactions (Avoid): - Strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole): may cause toxic levels of nifedipine. - Grapefruit juice: significantly increases plasma concentration. - Concurrent use with other potent vasodilators: risk of severe hypotension.

Moderate Interactions (Monitor Closely):\n- Beta‑blockers: additive effect on heart rate and blood pressure. - Digoxin: may increase digoxin serum levels. - Diuretics: potential electrolyte disturbances and enhanced hypotensive response.