Nifedipin Al (Nifedipine)

Nifedipine, the active ingredient in Nifedipin Al, is a calcium channel blocker presented as an oral tablet for oral use. It is used to lower high blood pressure, relieve chest pain from angina, and improve blood flow in Raynaud's phenomenon in adult patients.

GNH USA supplies Nifedipin Al as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Nifedipine acts on the cardiovascular system to manage conditions related to vascular tone and myocardial oxygen demand.

Hypertension: reduces systolic and diastolic blood pressure by relaxing arterial smooth muscle. Chronic stable angina: decreases myocardial oxygen consumption and alleviates chest pain. Raynaud's phenomenon: improves peripheral blood flow and reduces vasospastic attacks.

Nifedipine may cause a range of adverse reactions, from mild to serious.

Common Side Effects: - Headache: mild to moderate intensity, often transient. - Flushing: warmth and redness, typically on the face and neck. - Peripheral edema: swelling of ankles or feet due to fluid accumulation. - Dizziness: sensation of light‑headedness, especially on standing.

Serious or Rare Side Effects: - Severe hypotension: marked drop in blood pressure requiring medical attention. - Myocardial infarction: rare occurrence of heart attack. - Liver enzyme elevation: abnormal hepatic function tests. - Allergic reactions: rash, itching, or swelling of the face and throat. - Heart block: conduction abnormalities that may need monitoring.

Before initiating therapy, consider patient‑specific factors and monitor for adverse events.

Monitor blood pressure: ensure adequate control without excessive lowering. Avoid sudden position changes: reduce risk of orthostatic dizziness. Use caution in heart failure: may worsen fluid retention. Review concomitant CYP3A4 inhibitors: dose adjustment may be required. Store at room temperature: keep in the original pack, protect from moisture and direct sunlight.

Nifedipine can interact with several drug classes, altering its efficacy or safety.

Major Interactions (Avoid): - Strong CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin): increase plasma levels. - Grapefruit juice: can markedly raise nifedipine concentrations. - Concurrent use with other potent antihypertensives: may cause additive hypotension.

Moderate Interactions (Monitor Closely):\n- Beta‑blockers: may enhance bradycardia and hypotensive effects. - Diuretics: can amplify blood pressure reduction. - Digoxin: may increase risk of cardiac arrhythmias.