Nideolo (Dimethyl Fumarate)

Dimethyl Fumarate, the active ingredient in Nideolo, is an immunomodulator presented as an oral tablet for oral use. It is indicated for the treatment of multiple sclerosis and psoriasis in adult patients. GNH USA supplies Nideolo as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Dimethyl Fumarate acts on immune‑mediated pathways, primarily in neurological and dermatologic diseases. Multiple sclerosis: reduces relapse frequency and slows disability progression. Psoriasis: improves skin lesions and decreases disease severity.

Adverse reactions may occur with dimethyl fumarate therapy.

Common Side Effects: - Flushing: transient redness and warmth, often on the face. - Gastrointestinal discomfort: nausea, abdominal pain, or diarrhea. - Lymphopenia: mild reduction in lymphocyte count. - Headache: mild to moderate intensity. - Pruritus: itching without rash. - Fatigue: feeling unusually tired.

Serious or Rare Side Effects: - Progressive multifocal leukoencephalopathy (PML): rare but potentially fatal brain infection. - Severe lymphopenia: marked decrease in lymphocytes increasing infection risk. - Hepatic injury: elevated liver enzymes or hepatitis. - Severe infections: opportunistic bacterial, viral, or fungal infections. - Anaphylaxis: acute allergic reaction with airway compromise. - Stevens‑Johnson syndrome: severe skin and mucous membrane reaction.

Before initiating therapy, clinicians should assess baseline health status and monitor for specific risks. Monitor lymphocyte counts: baseline and periodic testing recommended. Assess hepatic function: check liver enzymes before initiation and during treatment. Avoid in patients with known hypersensitivity to dimethyl fumarate. Use caution in patients with active infections. Pregnancy and breastfeeding: safety not established; discuss risks with prescriber. Store at ambient temperature below 25°C: keep in the original pack, protect from moisture.

Dimethyl fumarate may interact with other medicines that affect the immune system or cause similar adverse effects.

Major Interactions (Avoid): - Immunosuppressants: may increase infection risk. - Live vaccines: contraindicated due to immunomodulation. - Drugs causing severe lymphopenia: avoid concurrent use.

Moderate Interactions (Monitor Closely): - Antidepressants (e.g., SSRIs): may intensify flushing. - Antihypertensives: monitor blood pressure as flushing can cause hypotension. - Antacids: may affect absorption; advise taking with water and spacing doses.