Nidef (Nifedipine)

Nifedipine, the active ingredient in Nidef, is a calcium channel blocker presented as an oral tablet for oral use. It treats hypertension and chronic stable angina in adult patients.

GNH USA supplies Nidef as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Nifedipine acts on the cardiovascular system to lower blood pressure and relieve chest pain.

Hypertension: reduces systemic arterial pressure and improves long‑term blood pressure control. Chronic stable angina: decreases frequency of angina attacks by improving myocardial oxygen supply. Raynaud's phenomenon: alleviates peripheral vasospasm and reduces ischemic episodes.

Nifedipine may cause several adverse reactions, ranging from mild to serious.

Common Side Effects: - Headache: mild to moderate intensity. - Flushing: transient warmth and redness of the skin. - Peripheral edema: swelling of the ankles or lower legs. - Dizziness: especially upon standing.

Serious or Rare Side Effects: - Severe hypotension: marked drop in blood pressure. - Myocardial infarction: rare but possible in high‑risk patients. - Hepatic dysfunction: abnormal liver enzymes or hepatitis.

Before initiating therapy, consider patient‑specific factors and monitor for adverse events.

Monitor blood pressure: ensure adequate control and avoid excessive drops. Avoid abrupt discontinuation: taper to prevent rebound hypertension. Use caution in hepatic impairment: dose adjustments may be required. Use caution in heart failure: monitor for fluid retention. Avoid concomitant grapefruit juice: may increase nifedipine levels. Store at room temperature: keep in the original container, protect from moisture.

Nifedipine can interact with several medicines, altering its effectiveness or safety.

Major Interactions (Avoid): - Strong CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin): increase plasma concentrations. - Simvastatin: risk of increased statin levels and myopathy. - Diltiazem or verapamil: additive cardiovascular depression.

Moderate Interactions (Monitor Closely):\n- Beta‑blockers: may enhance antihypertensive effect. - Diuretics: monitor electrolytes and blood pressure.