Nidagyl (Metronidazole)

Metronidazole, the active ingredient in Nidagyl, is a nitroimidazole antibiotic presented as an oral tablet for oral administration. It is used to treat anaerobic bacterial infections and selected protozoal diseases in both adult and pediatric patients when prescribed by a healthcare professional.

GNH USA supplies Nidagyl as a licensed, Good Distribution Practice‑compliant international pharmaceutical supplier, providing the product to hospitals, pharmacies, and clinics worldwide through regulated channels and ensuring quality and traceability for each batch, and supporting local regulatory requirements.

Metronidazole is employed to treat infections caused by anaerobic bacteria and susceptible protozoa.

- Bacterial vaginosis: restores normal vaginal flora by eliminating anaerobic bacteria. - Trichomoniasis: eradicates Trichomonas vaginalis, relieving symptoms and preventing transmission. - Amoebiasis: clears intestinal Entamoeba histolytica infection, reducing dysentery. - Giardiasis: eliminates Giardia lamblia, improving gastrointestinal function. - Anaerobic intra‑abdominal, pelvic, skin and soft‑tissue infections: provides bactericidal activity against mixed anaerobic flora. - Clostridioides difficile‑associated diarrhea (adjunct): reduces toxin‑producing bacterial load when used with standard therapy.

Metronidazole may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects: - Nausea: mild to moderate stomach upset. - Metallic taste: transient metallic sensation in the mouth. - Diarrhea: loose stools that may be watery. - Headache: mild to moderate head pain.

Serious or Rare Side Effects: - Seizures: convulsive episodes, especially with high plasma levels. - Peripheral neuropathy: tingling or numbness in extremities. - Severe allergic reactions: rash, swelling, or anaphylaxis.

When prescribing Metronidazole, consider the following precautions:

- Pregnancy: consult a healthcare provider as safety data are limited. - Alcohol: avoid consumption due to risk of a disulfiram‑like reaction. - Renal impairment: dose may require adjustment in severe kidney disease. - Hepatic disease: use with caution in patients with liver dysfunction. - Drug interactions: review all concomitant medications for potential interactions. - Store at room temperature: keep in the original container, protect from moisture and light.

Metronidazole can interact with several medicines; monitoring is essential.

Major Interactions (Avoid): - Alcohol: may cause severe flushing, tachycardia, and hypotension. - Warfarin: increased anticoagulant effect, raising bleeding risk. - Lithium: elevated lithium levels, potentially leading to toxicity.

Moderate Interactions (Monitor Closely): - Phenytoin: reduced phenytoin concentrations, possibly decreasing seizure control. - Cimetidine: may increase metronidazole plasma levels. - Oral contraceptives: possible reduction in contraceptive efficacy.