Nezallix (Azelastine Hydrochloride, Fluticasone Propionate)

Azelastine Hydrochloride and Fluticasone Propionate, the active ingredients in Nezallix, are an antihistamine/corticosteroid combination presented as a nasal spray for nasal use. It treats seasonal and perennial allergic rhinitis, relieving nasal congestion, itching and sneezing in both adults and children.

GNH USA supplies Nezallix as a licensed, GDP‑compliant international pharmaceutical supplier, providing the product to hospitals, pharmacies and clinics worldwide, with distribution aligned to EU regulatory standards and a supply chain that ensures product integrity and timely delivery.

Nezallix is indicated for allergic rhinitis, targeting the histamine and inflammatory pathways that cause nasal symptoms.

- Seasonal allergic rhinitis: reduces sneezing, itching, and nasal congestion during pollen seasons. - Perennial allergic rhinitis: provides continuous relief of nasal symptoms caused by year‑round allergens. - Nasal congestion due to allergy: diminishes swelling of nasal mucosa and improves airflow.

Adverse reactions to Nezallix may vary in frequency and severity.

Common Side Effects: - Nasal irritation or burning sensation - Bitter or unpleasant taste after spraying - Headache - Mild nosebleeds (epistaxis) - Transient cough

Serious or Rare Side Effects: - Severe allergic reaction (anaphylaxis) - Vision changes or cataract formation with long‑term use - Adrenal suppression from systemic corticosteroid exposure - Fungal sinusitis or opportunistic infection - Persistent nasal ulceration

Before using Nezallix, consider the following precautions. - Pregnancy: safety not established; discuss risks with a healthcare provider. - Breastfeeding: unknown effects; weigh benefits against potential risks. - Children: approved for use in specific age groups; follow prescribing information. - Concurrent nasal infections: avoid use until infection resolves to reduce irritation. - Use with other intranasal corticosteroids: may increase systemic exposure; limit combined use. - Store at room temperature: keep in the original container, protect from moisture and heat.

Nezallix may interact with other medicines; review the following categories.

Major Interactions (Avoid): - Strong CYP3A4 inhibitors (e.g., ketoconazole): may increase systemic fluticasone levels. - Live vaccines: systemic corticosteroid effect can diminish immune response. - Other intranasal corticosteroids: additive steroid exposure raises risk of systemic effects.

Moderate Interactions (Monitor Closely):\n- Oral antihistamines: may increase sedation when combined with sedating antihistamines. - Beta‑blockers: could mask signs of anaphylaxis if a severe allergic reaction occurs. - Nasal irritants (smoking, pollutants): may exacerbate local side effects.