Nexplanon (Etonogestrel)

Etonogestrel, the active ingredient in Nexplanon, is a progestin presented as a 68 mg subcutaneous implant for subcutaneous use. It provides long‑acting hormonal contraception by preventing ovulation and altering cervical mucus, and is indicated for women of reproductive age seeking reliable pregnancy prevention.

GNH USA supplies Nexplanon as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides regulatory documentation to support safe distribution across global markets, including temperature‑controlled shipping where required.

Etonogestrel, a progestin hormonal contraceptive, is used to prevent pregnancy by suppressing ovulation and modifying cervical mucus.

Prevention of pregnancy: provides up to three years of continuous contraception after insertion of the subcutaneous implant. Long‑acting reversible contraception: eliminates the need for daily pills, patches, or rings, offering a discreet method. Family planning: suitable for women who desire a reliable, low‑maintenance birth control option.

Etonogestrel may cause a range of adverse reactions, most of which are mild and transient.

Common Side Effects: - Irregular bleeding: changes in menstrual pattern, spotting or amenorrhea. - Headache: mild to moderate intensity. - Weight gain: modest increase in body weight. - Acne: new or worsening skin lesions.

Serious or Rare Side Effects: - Thromboembolic events: deep vein thrombosis or pulmonary embolism. - Severe allergic reaction: rash, swelling, or anaphylaxis. - Hepatic dysfunction: abnormal liver enzymes. - Pregnancy while using: ectopic or unintended pregnancy.

Before prescribing Nexplanon, clinicians should evaluate patient history and consider specific safety measures. - Assess cardiovascular risk: avoid in women with a history of thromboembolism. - Screen for liver disease: contraindicated in severe hepatic impairment. - Evaluate smoking status: caution in smokers over 35 years. - Consider bone health: monitor if risk factors for osteoporosis exist. - Counsel on insertion and removal: performed by trained healthcare professional. - Store at ambient temperature: keep in original packaging, protect from moisture and direct sunlight.

Etonogestrel can interact with other medicines that affect hormone metabolism or increase clotting risk.

Major Interactions (Avoid): - Enzyme inducers (e.g., rifampin, carbamazepine): may reduce contraceptive efficacy. - Anticoagulants (e.g., warfarin): may increase bleeding risk.

Moderate Interactions (Monitor Closely): - Antiepileptics (e.g., phenytoin): may modestly lower hormone levels. - Antiretrovirals (e.g., efavirenz): may decrease effectiveness. - Herbal supplements (e.g., St. John’s wort): may reduce plasma concentrations.