GNH USA

Europe — EMA

Nevrine Codeine (Paracetamol, Caffeine, Codeine Phosphate Hemihydrate)

GNH USA supplies Nevrine Codeine (Paracetamol / Caffeine / Codeine phosphate hemihydrate), an analgesic for moderate pain, headache and fever. Request quote.

Paracetamol, Caffeine, Codeine Phosphate Hemihydrate

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What is Paracetamol, Caffeine, Codeine Phosphate Hemihydrate?

Paracetamol / Caffeine / Codeine phosphate hemihydrate, the active ingredient in Nevrine Codeine, is an analgesic presented as an oral tablet for oral use. It provides pain relief and fever reduction for adults with mild to moderate pain. GNH USA supplies Nevrine Codeine as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

What is Paracetamol, Caffeine, Codeine Phosphate Hemihydrate used for?

Nevrine Codeine combines analgesic and antipyretic agents to treat pain and fever.

Mild to moderate pain: reduces discomfort from tension, musculoskeletal or dental sources. Headache: alleviates tension‑type and migraine‑associated headache. Fever: lowers elevated body temperature in febrile conditions.

What are the side effects of Paracetamol, Caffeine, Codeine Phosphate Hemihydrate?

Common Side Effects: - Nausea: mild to moderate upset stomach. - Constipation: reduced bowel movements. - Drowsiness: increased sleepiness. - Dizziness: sensation of light‑headedness. - Dry mouth: reduced salivation. - Insomnia: difficulty falling asleep, often from caffeine.

Serious or Rare Side Effects: - Respiratory depression: slowed breathing, especially in opioid‑naïve individuals. - Severe allergic reactions: rash, swelling, or anaphylaxis. - Hepatotoxicity: potential liver injury with high paracetamol exposure. - Dependence or addiction: risk with prolonged codeine use. - Seizures: rare but possible neurological event. - Low blood pressure: hypotension in susceptible patients.

What precautions apply to Paracetamol, Caffeine, Codeine Phosphate Hemihydrate?

Precautions should be observed before prescribing Nevrine Codeine.

Assess liver function: avoid in severe hepatic impairment. Monitor for respiratory depression: especially in opioid‑naïve patients. Avoid concomitant CNS depressants: may increase sedation. Use caution in pregnancy: risk assessment required. Avoid in children under 12 years: not recommended for this age group. Store at ambient temperature: keep in the original pack, protect from moisture and heat.

What does Paracetamol, Caffeine, Codeine Phosphate Hemihydrate interact with?

Nevrine Codeine may interact with several medicines.

Major Interactions (Avoid): - Other opioids: additive respiratory depression. - Benzodiazepines or barbiturates: increased CNS depression. - Alcohol: heightened sedation and respiratory risk. - Monoamine oxidase inhibitors (MAOIs): risk of serotonin syndrome. - CYP2D6 inhibitors (e.g., fluoxetine): may reduce codeine conversion.

Moderate Interactions (Monitor Closely): - CYP1A2 inducers (e.g., rifampicin): may reduce caffeine effect. - Anticoagulants (warfarin): may increase bleeding risk. - Diuretics: may enhance hypotensive effect.

Frequently asked questions

What is Nevrine Codeine used for?+
Nevrine Codeine is an oral combination product containing paracetamol, caffeine and codeine phosphate hemihydrate. It is used to relieve mild to moderate pain, treat headache and reduce fever in adult patients.
How does the active ingredient work?+
Paracetamol reduces prostaglandin synthesis by inhibiting central COX enzymes, caffeine blocks adenosine receptors to boost alertness and analgesia, and codeine is converted to morphine, which activates µ‑opioid receptors to provide pain relief and cough suppression.
What is the usual dose of Nevrine Codeine?+
The dose of Nevrine Codeine is determined by the prescribing clinician based on the patient’s condition, age, weight and other medications. The prescriber will set the appropriate strength and frequency.
Is Nevrine Codeine safe in pregnancy or breastfeeding?+
Safety in pregnancy and lactation has not been fully established. Use only if the potential benefit justifies the potential risk to the fetus or infant, and discuss with a healthcare professional before starting therapy.
How do I order Nevrine Codeine from GNH USA?+
To order, submit an enquiry on the product page at gnh-usa.com, specifying the required quantity. GNH USA works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any required import documentation.
How does Nevrine Codeine compare with other analgesics?+
Compared with single‑ingredient paracetamol products, Nevrine Codeine adds caffeine to enhance analgesia and codeine for opioid‑mediated pain control, offering stronger relief for moderate pain. It differs from pure opioid preparations by also providing antipyretic and stimulant effects.
What are the storage and handling requirements?+
Nevrine Codeine tablets should be stored at ambient temperature, below 25 °C, in the original container, protected from moisture and direct sunlight. Keep out of reach of children.
How is Nevrine Codeine administered?+
The product is taken orally, usually with a full glass of water. It may be taken with or without food, but patients should follow the prescriber’s instructions regarding timing and any food considerations.
What are the most serious risks to watch for?+
Serious risks include respiratory depression, severe allergic reactions, hepatotoxicity from excessive paracetamol, and the potential for dependence or addiction with prolonged codeine use. Patients should seek immediate medical attention if they experience difficulty breathing, rash, or unusual fatigue.
Who should not use Nevrine Codeine?+
Nevrine Codeine should be avoided in children under 12 years, patients with severe liver disease, known hypersensitivity to any component, those taking MAO inhibitors, and individuals with a history of opioid dependence unless specifically directed by a physician.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
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Product details

Drug
Paracetamol, Caffeine, Codeine Phosphate Hemihydrate
Route
Oral Use
Manufacturer
Laboratoires Sterop
Origin
EU

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