Nephrotect

Acetylcysteine, Glycine, L‑Lysine Acetate, L‑Tryptophan, Glycyl‑Tyrosine, L‑Arginine, L‑Histidine, the active ingredients in Nephrotect, are a nutritional supplement presented as an intravenous solution for intravenous use. It supports renal function and may be used in patients at risk of kidney injury, including those undergoing contrast studies or transplantation.

GNH USA supplies Nephrotect as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres and clinics worldwide.

Nephrotect is used as a renal‑support supplement that targets oxidative stress and metabolic pathways involved in kidney injury. - Acute kidney injury: helps mitigate oxidative damage and supports recovery of renal function. - Contrast‑induced nephropathy: provides antioxidant precursors that may reduce the incidence of contrast‑related renal impairment. - Chronic kidney disease adjunct: supplies amino acids that contribute to cellular protection and metabolic balance. - Renal transplantation support: assists in maintaining graft function by enhancing antioxidant capacity.

Nephrotect is generally well tolerated, but adverse reactions can occur.

Common Side Effects: - Mild nausea or vomiting. - Transient flushing or warmth at the infusion site. - Low‑grade headache. - Slight elevation of liver enzymes. - Mild hypotension during rapid infusion.

Serious or Rare Side Effects: - Anaphylactoid reactions, including rash, bronchospasm, or angioedema. - Severe hypotension requiring medical intervention. - Acute hemolysis in patients with glucose‑6‑phosphate dehydrogenase deficiency. - Renal tubular necrosis if administered inappropriately. - Persistent elevation of serum creatinine despite therapy.

Nephrotect should be used with clinical oversight and appropriate monitoring. - Patient assessment: evaluate renal function and baseline labs before initiation. - Infusion rate: administer slowly to reduce risk of hypotension and flushing. - Allergy history: screen for known hypersensitivity to any component. - G6PD deficiency: avoid or monitor closely due to risk of hemolysis. - Storage: Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Nephrotect may interact with other agents that affect oxidative balance or renal hemodynamics.

Major Interactions (Avoid): - High‑dose N‑acetylcysteine oral formulations: risk of cumulative sulfhydryl overload. - Potent vasodilators (e.g., nitroprusside): may exacerbate hypotension.

Moderate Interactions (Monitor Closely): - Loop diuretics: monitor electrolytes and volume status. - ACE inhibitors or ARBs: watch for additive effects on renal perfusion. - Anticoagulants: observe for any changes in bleeding tendency due to altered platelet function.