Neotigason (Acitretin)

Acitretin, the active ingredient in Neotigason, is a retinoid presented as an oral tablet for systemic use. It is prescribed for severe forms of psoriasis and other disorders of keratinization in adult patients.

GNH USA supplies Neotigason as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Neotigason is a retinoid that acts on abnormal keratinocyte proliferation and differentiation in skin disorders. - Severe psoriasis: reduces plaque formation and improves skin clearance. - Plaque psoriasis: helps control extensive lesions resistant to topical therapy. - Disorders of keratinization: normalizes skin scaling in conditions such as congenital ichthyosis.

Acitretin may cause a range of adverse reactions that vary in frequency and severity.

Common Side Effects: - Dry skin: increased xerosis and scaling. - Elevated triglycerides: hyperlipidaemia requiring monitoring. - Hair loss: temporary alopecia. - Cheilitis: cracked or inflamed lips. - Headache: mild to moderate intensity. - Nausea: occasional gastrointestinal upset.

Serious or Rare Side Effects: - Hepatotoxicity: signs of liver dysfunction. - Pseudotumor cerebri: headache with visual changes. - Severe hyperlipidaemia: markedly high cholesterol or triglycerides. - Bone toxicity: premature epiphyseal closure in adolescents. - Severe skin reactions: Stevens‑Johnson syndrome or toxic epidermal necrolysis. - Depression or mood changes: rare psychiatric effects.

Before initiating therapy, clinicians should assess baseline labs and patient risk factors. - Pregnancy contraindication: Acitretin is teratogenic (Category X) and must not be used by women of childbearing potential. - Liver function: monitor hepatic enzymes regularly. - Lipid profile: check triglycerides and cholesterol before and during treatment. - Bone health: avoid use in growing adolescents due to risk of premature epiphyseal closure. - Concomitant vitamin A: avoid additional vitamin A supplements to reduce toxicity risk. - Store at ambient temperature: keep below 25°C, in the original packaging, protected from moisture and light.

Acitretin can interact with several medications, altering efficacy or safety.

Major Interactions (Avoid): - Tetracyclines: increased risk of intracranial hypertension. - Vitamin A supplements: additive teratogenic and toxicity risk. - Oral contraceptives: reduced effectiveness; alternative contraception required.

Moderate Interactions (Monitor Closely): - Lipid‑lowering agents (e.g., fibrates, statins): may exacerbate hyperlipidaemia. - Antifungal azoles: potential for increased serum Acitretin levels. - Methotrexate: additive hepatotoxicity; monitor liver function. - Warfarin: possible alteration of INR; check coagulation parameters.