Neotigason (Acitretin)

Acitretin, the active ingredient in Neotigason, is a retinoid presented as an oral tablet for systemic use. It is indicated for the treatment of severe psoriasis and other disorders of keratinization in adult patients. GNH USA supplies Neotigason as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Neotigason is a retinoid used in dermatology to normalize skin cell growth and differentiation. - Severe psoriasis: reduces plaque formation and improves skin appearance. - Psoriatic keratoderma: softens thickened skin on palms and soles. - Disorders of keratinization: helps normalize abnormal keratinocyte proliferation.

Acitretin may cause a range of adverse reactions that vary in frequency and severity.

Common Side Effects: - Dry skin and mucous membranes: dryness of lips, eyes, and nasal passages. - Elevated liver enzymes: mild, transient increases in hepatic transaminases. - Hyperlipidaemia: rise in triglycerides and cholesterol levels. - Hair loss: temporary alopecia or thinning. - Headache: mild to moderate intensity. - Gastrointestinal discomfort: nausea or abdominal pain.

Serious or Rare Side Effects: - Severe hepatic dysfunction: jaundice, hepatitis, or liver failure. - Pancreatitis: acute inflammation of the pancreas. - Pseudotumor cerebri: increased intracranial pressure causing visual disturbances. - Severe hypertriglyceridaemia: risk of pancreatitis. - Depression or mood changes: rare but clinically significant. - Skeletal toxicity: premature epiphyseal closure in children or bone demineralisation.

Acitretin requires careful monitoring due to its potent pharmacologic profile. - Pregnancy: contraindicated; teratogenic risk persists up to 3 years after discontinuation. - Liver function: assess baseline enzymes and monitor periodically. - Lipid profile: check fasting triglycerides and cholesterol before and during therapy. - Alcohol use: avoid excessive intake as it may increase hepatotoxicity. - Concomitant vitamin A: avoid additional retinoids to prevent cumulative toxicity. - Store below 25°C: keep in the original container, protect from moisture and direct sunlight.

Acitretin can interact with several medicines, altering efficacy or safety.

Major Interactions (Avoid): - Tetracyclines: increased risk of intracranial hypertension. - Vitamin A supplements or other retinoids: additive teratogenic and toxicity risk. - Cholestyramine or colestipol: reduces acitretin absorption, lowering effectiveness.

Moderate Interactions (Monitor Closely): - Oral contraceptives: reduced hormonal efficacy, necessitating alternative contraception. - Warfarin: potential alteration of INR, requiring closer coagulation monitoring. - Statins: may exacerbate lipid abnormalities; monitor lipid levels.