Neotigason (Acitretin)

Acitretin, the active ingredient in Neotigason, is a retinoid presented as an oral tablet for oral use. It is indicated for the treatment of severe psoriasis in adult patients, helping to normalize epidermal growth and reduce plaque formation. It is prescribed when topical therapies are insufficient and is part of systemic management strategies for chronic plaque psoriasis.

GNH USA supplies Neotigason as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides reliable logistics for global distribution.

Acitretin is a systemic retinoid used in the management of severe psoriasis, a chronic inflammatory skin disorder. - Severe plaque psoriasis: reduces plaque thickness, scaling and erythema. - Generalized pustular psoriasis: helps control pustule formation and inflammation. - Disorders of keratinization (e.g., ichthyosis): normalizes epidermal differentiation in conditions such as ichthyosis.

Acitretin may cause a range of adverse reactions, which are grouped by frequency.

Common Side Effects: - Dry skin: increased epidermal dryness and scaling. - Cheilitis: inflammation and cracking of the lips. - Hair loss: temporary thinning of scalp hair. - Headache: mild to moderate cephalic discomfort. - Elevated liver enzymes: mild transaminase rise. - Hyperlipidaemia: increase in serum cholesterol and triglycerides.

Serious or Rare Side Effects: - Teratogenicity: severe fetal malformations if exposure occurs during pregnancy. - Severe hepatic injury: rare cases of liver failure. - Pancreatitis: inflammation of the pancreas. - Depression or mood changes: rare psychiatric effects. - Pseudotumor cerebri: increased intracranial pressure. - Severe hypertriglyceridaemia: risk of pancreatitis.

Before initiating therapy, clinicians should consider several safety measures. - Pregnancy contraindication: avoid use in pregnant women and women of childbearing potential. - Contraception requirement: effective birth control must be used during treatment and for at least three years after discontinuation. - Liver function monitoring: assess baseline and periodic hepatic enzymes. - Lipid profile monitoring: check serum lipids before and during therapy. - Alcohol avoidance: limit alcohol to reduce hepatic risk. - Store at ambient temperature: keep in the original pack, protect from moisture and direct sunlight.

Acitretin can interact with other medicines, requiring attention to avoid adverse outcomes.

Major Interactions (Avoid): - Tetracyclines: increased risk of intracranial hypertension. - Vitamin A supplements: additive retinoid toxicity. - Oral contraceptives: reduced efficacy, increasing teratogenic risk.

Moderate Interactions (Monitor Closely): - Statins: potential for altered lipid levels. - Antifungal agents (e.g., ketoconazole): may affect hepatic metabolism of acitretin.