Europe — EMA
Neoral (Ciclosporin)
GNH USA supplies Neoral (ciclosporin), a calcineurin inhibitor for transplant rejection, psoriasis and rheumatoid arthritis. Request a quote for supply.
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What is Ciclosporin?
ciclosporin, the active ingredient in Neoral, is a calcineurin inhibitor presented as a oral solution for oral use. It treats organ transplant rejection, severe psoriasis and rheumatoid arthritis in appropriate patients.
GNH USA supplies Neoral as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, transplant centres, pharmacies and clinics worldwide.
What is Ciclosporin used for?
Neoral, a calcineurin inhibitor, is employed in immune‑mediated conditions to prevent graft loss and control inflammatory disease.
Organ transplant rejection: prevents graft rejection by suppressing T‑cell activation. Severe psoriasis: reduces skin inflammation and plaque formation. Rheumatoid arthritis: diminishes joint inflammation and disease activity.
What are the side effects of Ciclosporin?
Neoral may cause a range of adverse reactions that vary in frequency and severity.
Common Side Effects: - Headache - Tremor - Nausea - Hypertension - Gingival hyperplasia
Serious or Rare Side Effects: - Nephrotoxicity (reduced kidney function) - Increased susceptibility to infections - Elevated liver enzymes - Risk of malignancies with long‑term use - Severe allergic reactions (anaphylaxis)
What precautions apply to Ciclosporin?
Before initiating therapy, clinicians should assess baseline organ function and monitor patients regularly.
Monitor renal function: regular serum creatinine and eGFR assessments. Check blood pressure: manage hypertension promptly. Assess liver enzymes: periodic ALT/AST testing. Screen for infections: evaluate and treat active infections before starting. Avoid concomitant nephrotoxic drugs: adjust dosing or discontinue when possible. Store at ambient temperature: keep in the original container, protect from moisture and light.
What does Ciclosporin interact with?
Ciclosporin interacts with several drug classes that can alter its plasma concentration or increase toxicity.
Major Interactions (Avoid): - Strong CYP3A4 inhibitors (e.g., ketoconazole): may cause toxic levels. - Nephrotoxic antibiotics (e.g., aminoglycosides): increase risk of kidney damage. - mTOR inhibitors (e.g., sirolimus): additive immunosuppression.
Moderate Interactions (Monitor Closely): - Calcium channel blockers (e.g., diltiazem): may raise ciclosporin levels. - Statins (e.g., simvastatin): risk of myopathy. - NSAIDs: potential renal impairment.
