Europe — EMA
Neophyr (Nitric Oxide)
GNH USA supplies Neophyr (Nitric Oxide), a pulmonary vasodilator for persistent pulmonary hypertension of the newborn, ARDS and pulmonary hypertension.
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What is Nitric Oxide?
Nitric Oxide, the active ingredient in Neophyr, is a pulmonary vasodilator presented as a medical gas for inhalation use. It treats pulmonary hypertension and related conditions such as persistent pulmonary hypertension of the newborn and acute respiratory distress syndrome. GNH USA supplies Neophyr as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide.
What is Nitric Oxide used for?
Neophyr acts on the pulmonary vasculature to lower vascular resistance in several serious respiratory conditions.
- Persistent pulmonary hypertension of the newborn (PPHN): improves oxygenation by reducing pulmonary vascular resistance. - Acute respiratory distress syndrome (ARDS): facilitates pulmonary vasodilation to support gas exchange. - Pulmonary hypertension: lowers pulmonary arterial pressure and alleviates right‑ventricular strain.
What are the side effects of Nitric Oxide?
Adverse reactions may occur with inhaled nitric oxide therapy.
Common Side Effects: - Cough or throat irritation - Headache - Dizziness - Flushing - Mild hypotension - Nausea
Serious or Rare Side Effects: - Methemoglobinemia - Severe hypotension - Pulmonary edema - Allergic reaction (anaphylaxis) - Respiratory failure - Hemorrhage
What precautions apply to Nitric Oxide?
Use of Neophyr requires careful monitoring and specific safety measures. - Blood pressure monitoring: watch for sudden drops in systemic pressure. - Oxygenation assessment: ensure adequate arterial oxygen levels during therapy. - Cardiovascular stability: avoid in patients with unstable heart conditions. - Hypersensitivity: discontinue if signs of allergic reaction appear. - Interaction with other vasodilators: adjust therapy as needed. - Store at ambient temperature: keep cylinder upright, protect from heat and direct sunlight.
What does Nitric Oxide interact with?
Nitric Oxide can interact with several agents that affect vascular tone or nitric oxide pathways.
Major Interactions (Avoid): - Phosphodiesterase‑5 inhibitors (e.g., sildenafil): risk of profound hypotension. - Inhaled anesthetics (e.g., nitrous oxide): additive vasodilatory effect. - Methylene blue: reduces nitric oxide efficacy.
Moderate Interactions (Monitor Closely): - Other pulmonary vasodilators (e.g., prostacyclin analogues): may enhance vasodilation. - Systemic vasodilators (e.g., nitroglycerin): monitor blood pressure. - Certain antibiotics (e.g., aminoglycosides): may affect nitric oxide metabolism.
