Neohepatect (Human Hepatitis B Immunoglobulin)

Human Hepatitis B Immunoglobulin, the active ingredient in Neohepatect, is an Immunoglobulin presented as an injection solution for intravenous use. It provides passive immunity against hepatitis B virus and is used for post‑exposure prophylaxis and to prevent HBV recurrence after liver transplantation.

GNH USA supplies Neohepatect as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres and pharmacies worldwide.

Neohepatect, a human hepatitis B immunoglobulin, is employed in antiviral prophylaxis and post‑transplant management. - Post‑exposure prophylaxis of hepatitis B: provides immediate passive immunity to prevent infection after exposure. - Prevention of HBV recurrence after liver transplantation: supplies anti‑HBs antibodies to reduce viral reactivation in transplant recipients. - Supplementation in individuals with low anti‑HBs antibody levels: enhances protective immunity against hepatitis B virus.

Common Side Effects: - Fever or chills - Headache - Nausea or vomiting - Injection‑site pain or erythema - Fatigue or malaise - Transient hypotension

Serious or Rare Side Effects: - Anaphylactic or severe allergic reactions - Serum sickness‑like syndrome - Hemolysis or renal impairment - Thrombosis or embolic events - Severe hypotension requiring intervention - Acute respiratory distress

Neohepatect requires careful clinical assessment before use. - Assess HBV serology: confirm need for passive immunization. - Monitor infusion: watch for allergic reactions during administration. - Use caution in cardiovascular disease: avoid rapid infusion rates. - Avoid mixing with incompatible solutions: follow manufacturer guidelines. - Do not administer to patients with known IgA deficiency without specialist advice. - Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Neohepatect may interact with other biologics and medications. Major Interactions (Avoid): - Concurrent immunoglobulin products: risk of immunoglobulin overload. - Live vaccines: may diminish vaccine efficacy. - High‑dose steroids: could alter antibody clearance. Moderate Interactions (Monitor Closely): - Heparin or anticoagulants: monitor for bleeding tendencies. - ACE inhibitors or ARBs: observe blood pressure changes. - Diuretics: watch fluid and electrolyte balance.