Neofen (Ibuprofen)

Ibuprofen, the active ingredient in Neofen, is a nonsteroidal anti-inflammatory drug (NSAID) presented as a rectal formulation for rectal use. It treats pain, fever and inflammation in adults and children as directed.

GNH USA supplies Neofen as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Ibuprofen acts systemically to reduce inflammation and relieve symptoms associated with several common conditions.

- Pain: provides analgesic relief for mild to moderate nociceptive pain. - Fever: reduces elevated body temperature by acting on the hypothalamic heat-regulating center. - Inflammation: diminishes swelling and redness in inflammatory conditions such as musculoskeletal injuries.

Adverse reactions may vary in frequency and severity.

Common Side Effects: - Gastrointestinal discomfort: nausea, dyspepsia or mild abdominal pain. - Headache: transient headache episodes. - Dizziness: occasional light‑headedness. - Rash: mild skin erythema or itching. - Elevated blood pressure: modest rise in systolic/diastolic values.

Serious or Rare Side Effects: - Gastrointestinal ulceration or bleeding. - Severe allergic reactions: anaphylaxis, angioedema. - Hepatotoxicity: elevated liver enzymes or hepatitis. - Renal impairment: acute kidney injury, especially with dehydration. - Cardiovascular events: increased risk of myocardial infarction or stroke.

Before using Neofen, consider the following safety measures.

- Assess gastrointestinal risk: avoid in patients with active ulcers or severe GI disease. - Monitor renal function: use cautiously in those with existing kidney impairment. - Evaluate cardiovascular status: limit use in patients with uncontrolled hypertension or heart disease. - Review concomitant NSAID or anticoagulant therapy: increase bleeding risk. - Pregnancy and lactation: consult a healthcare professional before use. - Store at ambient temperature: keep below 25°C in the original packaging, protected from moisture and direct sunlight.

Ibuprofen can interact with several drug classes, requiring attention to avoid adverse outcomes.

Major Interactions (Avoid): - Anticoagulants (e.g., warfarin): heightened bleeding risk. - High‑dose aspirin: increased gastrointestinal toxicity. - Selective COX‑2 inhibitors: additive renal and cardiovascular effects.

Moderate Interactions (Monitor Closely): - ACE inhibitors or ARBs: possible reduction in antihypertensive efficacy and renal function. - Diuretics: may enhance nephrotoxic potential. - Lithium: ibuprofen can raise serum lithium levels. - Methotrexate: reduced clearance leading to toxicity.