Neofen (Ibuprofen)

Ibuprofen, the active ingredient in Neofen, is a nonsteroidal anti‑inflammatory drug (NSAID) presented as an oral dosage form for oral use. It treats pain, fever and inflammation in adults and children when prescribed by a healthcare professional.

GNH USA supplies Neofen as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Ibuprofen works by reducing inflammation and relieving symptoms in several common conditions.

- Mild to moderate pain: provides analgesia for headaches, dental pain, musculoskeletal aches, and dysmenorrhea. - Fever: lowers elevated body temperature associated with infections or inflammatory states. - Inflammatory disorders: helps control swelling and discomfort in conditions such as osteoarthritis and rheumatoid arthritis.

Adverse reactions may vary in frequency and severity.

Common Side Effects: - Gastrointestinal discomfort: nausea, dyspepsia, or abdominal pain. - Headache or dizziness. - Mild skin rash or itching. - Elevated blood pressure in susceptible individuals. - Transient elevation of liver enzymes.

Serious or Rare Side Effects: - Gastrointestinal ulceration or bleeding. - Severe hypersensitivity reactions, including anaphylaxis. - Renal impairment or acute kidney injury. - Hepatotoxicity with marked liver enzyme rise. - Cardiovascular events such as myocardial infarction or stroke, especially with high‑dose or prolonged use.

Before using Ibuprofen, consider the following safety measures.

- Assess gastrointestinal risk: avoid in patients with active ulcers or a history of GI bleeding. - Evaluate cardiovascular status: use cautiously in individuals with hypertension, heart disease, or stroke risk. - Monitor renal function: contraindicated in severe renal impairment or dehydration. - Review concomitant medications: avoid concurrent use with other NSAIDs or anticoagulants without medical guidance. - Pregnancy and lactation: discuss risks with a healthcare provider before use. - Store at ambient temperature: keep below 25 °C, retain in original packaging, and protect from moisture.

Ibuprofen may interact with several drug classes, requiring attention to dosage and monitoring.

Major Interactions (Avoid): - Anticoagulants (e.g., warfarin): increased bleeding risk. - High‑dose aspirin: heightened gastrointestinal toxicity. - Selective COX‑2 inhibitors: additive renal and cardiovascular adverse effects.

Moderate Interactions (Monitor Closely): - ACE inhibitors or ARBs: possible reduction in antihypertensive efficacy and renal function. - Diuretics: may enhance nephrotoxic potential. - Lithium: NSAIDs can raise serum lithium levels. - Methotrexate: reduced clearance leading to toxicity.