Neofel Xl (Felodipine)

Felodipine, the active ingredient in Neofel Xl, is a calcium channel blocker (dihydropyridine) presented as a tablet for oral use. It treats essential hypertension and angina pectoris in adult patients.

GNH USA supplies Neofel Xl as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Neofel Xl, a calcium channel blocker, is used to manage conditions related to elevated vascular resistance and cardiac ischemia.

Essential hypertension: lowers systolic and diastolic blood pressure by reducing peripheral vascular resistance. Angina pectoris: alleviates chest pain by improving coronary blood flow. Stable angina: decreases frequency of anginal attacks through arterial vasodilation.

Common Side Effects: - Headache: mild to moderate intensity. - Flushing: transient warmth and redness of the skin. - Peripheral edema: swelling of the ankles or feet. - Dizziness: sensation of light‑headedness, especially on standing. - Nausea: mild gastrointestinal discomfort. - Tachycardia: increased heart rate.

Serious or Rare Side Effects: - Severe hypotension: marked drop in blood pressure requiring medical attention. - Myocardial infarction: rare occurrence of heart attack. - Hepatic dysfunction: abnormal liver enzyme elevations. - Allergic reactions: rash, pruritus, or anaphylaxis. - Neutropenia: low white‑blood‑cell count. - Stevens‑Johnson syndrome: severe skin reaction.

Neofel Xl should be used with careful clinical monitoring.

Monitor blood pressure: adjust therapy if target levels are not achieved. Assess cardiac status: watch for signs of ischemia or worsening angina. Review concomitant antihypertensives: avoid excessive hypotension. Use caution in hepatic impairment: dose may need adjustment. Store at room temperature: keep in the original pack, protect from moisture.

Felodipine may interact with several medicines; clinicians should evaluate potential risks.

Major Interactions (Avoid): - Strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole): may increase felodipine levels. - Concurrent potent vasodilators (e.g., nitroglycerin): risk of severe hypotension. - Grapefruit juice: can elevate plasma concentrations.

Moderate Interactions (Monitor Closely): - CYP3A4 inducers (e.g., rifampin, carbamazepine): may reduce efficacy. - Non‑dihydropyridine calcium channel blockers: additive cardiac effects. - Beta‑blockers: may blunt compensatory tachycardia. - Diuretics: enhanced blood‑pressure lowering effect.