Neobrufen Retard (Ibuprofen)

Ibuprofen, the active ingredient in Neobrufen Retard, is a nonsteroidal anti-inflammatory drug presented as an oral tablet for oral use. It provides analgesic relief, reduces fever, and diminishes inflammation in adults and children when prescribed appropriately, offering a reliable option for short‑term symptom management. It is also employed in the treatment of musculoskeletal discomfort and menstrual cramps.

GNH USA supplies Neobrufen Retard as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, ensuring consistent quality and regulatory compliance across global markets.

Neobrufen Retard (ibuprofen) is used to manage conditions involving pain, fever and inflammation across various disease groups. - Pain: Provides analgesic relief for mild to moderate nociceptive pain. - Fever: Lowers elevated body temperature associated with infectious or inflammatory processes. - Inflammation: Reduces swelling and redness in musculoskeletal and soft‑tissue conditions. - Arthritis: Alleviates joint pain and stiffness in osteoarthritis and rheumatoid arthritis. - Dysmenorrhea: Relieves menstrual cramps and associated discomfort. - Headache: Mitigates tension‑type and mild migraine headaches.

Ibuprofen may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects: - Gastrointestinal upset: nausea, dyspepsia, or abdominal discomfort. - Headache: mild to moderate tension‑type headache. - Dizziness or vertigo. - Skin rash or mild itching.

Serious or Rare Side Effects: - Gastrointestinal bleeding or ulcer perforation. - Acute renal impairment or worsening of chronic kidney disease. - Hepatotoxicity with elevated liver enzymes. - Anaphylactic or severe allergic reactions. - Stevens‑Johnson syndrome or toxic epidermal necrolysis.

When prescribing or dispensing ibuprofen, consider the following precautions to minimize risk. - Assess renal function: Evaluate kidney health, especially in patients with dehydration or chronic disease. - Evaluate gastrointestinal risk: Use with caution in individuals with a history of ulcers or bleeding. - Use lowest effective dose: Limit duration and dose to the minimum needed for symptom control. - Avoid in known hypersensitivity: Do not administer to patients with previous ibuprofen or NSAID allergy. - Monitor in elderly: Elderly patients may be more susceptible to adverse effects and drug interactions. - Store at room temperature: Keep in the original container, protect from moisture and heat.

Ibuprofen can interact with several medicines, altering efficacy or safety.

Major Interactions (Avoid): - Anticoagulants (e.g., warfarin): increased risk of bleeding. - Selective serotonin reuptake inhibitors (SSRIs): heightened gastrointestinal bleeding risk. - Lithium: possible increase in lithium serum levels. - ACE inhibitors or ARBs: may reduce renal perfusion. - Diuretics: risk of renal function decline.

Moderate Interactions (Monitor Closely): - Methotrexate: reduced clearance, potential toxicity. - Cyclosporine: increased nephrotoxicity. - Antihypertensive agents: possible attenuation of blood‑pressure‑lowering effect. - Antidiabetic drugs: may affect glycemic control. - Allopurinol: rare reports of hypersensitivity reactions.