Neobrufen (Ibuprofen)

Ibuprofen, the active ingredient in Neobrufen, is a nonsteroidal anti-inflammatory drug presented as an oral tablet for oral use. It treats mild to moderate pain, fever, and inflammatory conditions such as osteoarthritis and rheumatoid arthritis.\n\nGNH India supplies Neobrufen as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Neobrufen, an NSAID, works on inflammatory pathways to relieve discomfort in several common conditions.\n\nPain: Reduces mild to moderate acute or chronic pain.\nFever: Lowers elevated body temperature.\nOsteoarthritis: Alleviates joint pain and improves mobility.\nRheumatoid arthritis: Decreases inflammation and pain associated with disease activity.

Ibuprofen may cause a range of adverse reactions, most of which are predictable and dose‑related.\n\nCommon Side Effects:\n- Gastrointestinal discomfort such as dyspepsia or heartburn.\n- Nausea or mild vomiting.\n- Headache or dizziness.\n- Mild skin rash or itching.\n- Elevated blood pressure in susceptible individuals.\n\nSerious or Rare Side Effects:\n- Gastrointestinal ulceration or bleeding.\n- Severe allergic reactions including anaphylaxis.\n- Renal impairment or acute kidney injury.\n- Hepatotoxicity with elevated liver enzymes.\n- Cardiovascular events such as myocardial infarction or stroke, especially with prolonged use.

Before using Neobrufen, consider the following safety measures.\n\nAssess gastrointestinal risk: Avoid use in patients with active ulcers or a history of GI bleeding.\nMonitor renal function: Use caution in individuals with existing kidney disease.\nCheck cardiovascular status: Limit use in patients with uncontrolled hypertension or heart disease.\nAvoid concurrent NSAIDs: Do not combine with other non‑steroidal anti‑inflammatory drugs.\nPregnancy and lactation: Consult a healthcare professional before use.\nStore at ambient temperature: Keep below 25°C in the original packaging, protected from moisture and direct sunlight.

Ibuprofen can interact with several drug classes, altering efficacy or safety.\n\nMajor Interactions (Avoid):\n- Anticoagulants (e.g., warfarin): Increased bleeding risk.\n- High‑dose aspirin: Enhanced gastrointestinal toxicity.\n- Certain antihypertensives (e.g., ACE inhibitors, ARBs): May reduce blood pressure control.\n\nModerate Interactions (Monitor Closely):\n- Diuretics: Potential reduction in renal perfusion.\n- Lithium: Possible increase in lithium levels.\n- Methotrexate: Decreased clearance leading to toxicity.