Neo-Lotan Plus (Losartan Potassium, Hydrochlorothiazide)

Losartan potassium, the active ingredient in Neo-Lotan Plus, is an angiotensin II receptor blocker presented as an oral tablet for oral use. It is combined with hydrochlorothiazide to treat hypertension in adult patients by lowering blood pressure through vascular relaxation and reduced fluid volume.

GNH USA supplies Neo-Lotan Plus as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides reliable logistics for global distribution. Customers benefit from consistent product availability and regulatory compliance support.

Neo-Lotan Plus, a combined angiotensin II receptor blocker and thiazide diuretic, is indicated for conditions related to elevated blood pressure.

- Essential hypertension: lowers systolic and diastolic pressure and reduces cardiovascular risk. - Stage 2 hypertension: adds diuretic effect to achieve target blood pressure when monotherapy is insufficient. - Hypertension with fluid retention: combines vasodilation and diuresis for improved blood‑pressure control.

Common Side Effects: - Dizziness: feeling light‑headed, especially after standing. - Headache: mild to moderate pain in the head region. - Fatigue: general tiredness or lack of energy. - Increased urination: more frequent need to void due to diuretic action. - Low potassium (hypokalemia): reduced serum potassium levels. - Mild gastrointestinal upset: nausea or abdominal discomfort.

Serious or Rare Side Effects: - Severe allergic reaction (anaphylaxis): rash, swelling, difficulty breathing. - Acute kidney injury: sudden decrease in renal function. - Hyperkalemia: dangerously high potassium levels. - Severe hypotension: markedly low blood pressure causing fainting. - Pancreatitis: inflammation of the pancreas with abdominal pain.

Neo-Lotan Plus should be used with careful clinical monitoring.

- Blood pressure monitoring: check regularly to avoid excessive hypotension. - Renal function assessment: evaluate serum creatinine and eGFR before and during therapy. - Electrolyte surveillance: monitor potassium and sodium levels, especially in patients on other diuretics. - Pregnancy avoidance: contraindicated in pregnancy due to fetal toxicity risk. - Elderly caution: start at lower dose and monitor for orthostatic effects. - Store at ambient temperature: keep in the original container, protect from moisture and direct sunlight.

Neo-Lotan Plus may interact with several medicines; clinical judgment is required.

Major Interactions (Avoid): - ACE inhibitors or aliskiren: risk of additive hyperkalemia and renal impairment. - Potassium supplements or potassium‑sparing diuretics: may cause dangerous hyperkalemia. - Lithium: increased lithium concentrations leading to toxicity. - NSAIDs (e.g., ibuprofen, naproxen): can reduce antihypertensive efficacy and affect renal function. - Strong CYP2C9 inhibitors (e.g., fluconazole): may raise losartan levels.

Moderate Interactions (Monitor Closely): - Other antihypertensives (beta‑blockers, calcium channel blockers): additive blood‑pressure lowering effect. - Additional thiazide or loop diuretics: may cause excessive diuresis and electrolyte disturbances. - Antidiabetic agents: hydrochlorothiazide can raise blood glucose, requiring dose adjustment.