Europe — EMA
Nefopam Holsten (Nefopam Hydrochloride)
GNH USA supplies Nefopam Holsten (Nefopam), a non‑opioid analgesic for moderate acute pain, post‑operative pain and musculoskeletal pain.
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What is Nefopam Hydrochloride?
Nefopam, the active ingredient in Nefopam Holsten, is a non‑opioid analgesic presented as an oral formulation for oral use. It treats moderate acute pain, post‑operative pain and musculoskeletal pain in adult patients.
GNH USA supplies Nefopam Holsten as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.
What is Nefopam Hydrochloride used for?
Nefopam is a non‑opioid analgesic used to manage pain conditions.
- Moderate acute pain: provides relief of pain of moderate intensity in adult patients. - Post‑operative pain: reduces pain following surgical procedures. - Musculoskeletal pain: alleviates pain associated with muscle and joint disorders.
What are the side effects of Nefopam Hydrochloride?
Nefopam may cause a range of adverse reactions, varying from mild to severe.
Common Side Effects: - Nausea: mild gastrointestinal upset. - Dry mouth: reduced salivation. - Sweating: increased perspiration. - Dizziness: transient light‑headedness.
Serious or Rare Side Effects: - Seizures: rare occurrence of convulsive episodes. - Tachycardia: rapid heart rate that may require medical attention. - Hypotension: significant drop in blood pressure.
What precautions apply to Nefopam Hydrochloride?
When prescribing Nefopam, clinicians should consider several safety factors.
- Renal impairment: adjust use in patients with reduced kidney function. - Hepatic dysfunction: caution in liver disease. - Cardiovascular disease: monitor heart rate and blood pressure. - Seizure history: avoid in patients with epilepsy. - Concomitant MAO inhibitors: contraindicated due to risk of hypertensive crisis. - Store at ambient temperature: keep below 25°C in the original pack, protect from moisture.
What does Nefopam Hydrochloride interact with?
Nefopam interacts with several drug classes; awareness of the interaction level is essential.
Major Interactions (Avoid): - MAO inhibitors: risk of severe hypertension. - Antidepressants (SSRIs, SNRIs): may increase serotonergic effects.
Moderate Interactions (Monitor Closely): - Antihypertensives: may potentiate blood‑pressure lowering. - Anticholinergic drugs: additive dry‑mouth effect. - CNS stimulants: may increase seizure risk.
