Nefazol (Cefazolin Sodium)

Cefazolin Sodium, the active ingredient in Nefazol, is a cephalosporin presented as a sterile powder for intramuscular injection. It is used to treat bacterial infections and is commonly employed for surgical prophylaxis and a range of community‑acquired infections in adult patients.

GNH USA supplies Nefazol as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide.

Cefazolin Sodium is a broad‑spectrum cephalosporin that targets Gram‑positive and some Gram‑negative bacteria, making it suitable for several infection categories.

- Surgical prophylaxis: prevents postoperative bacterial infections in patients undergoing operative procedures. - Skin and soft tissue infections: treats cellulitis and wound infections caused by susceptible organisms. - Bone and joint infections: used for osteomyelitis and septic arthritis when pathogens are sensitive. - Urinary tract infections: effective against uncomplicated UTIs caused by susceptible bacteria. - Respiratory tract infections: manages community‑acquired pneumonia and bronchitis when indicated.

Adverse reactions to cefazolin may vary in frequency and severity.

Common Side Effects: - Injection site pain or erythema - Rash or mild skin itching - Nausea or vomiting - Diarrhea - Transient elevation of liver enzymes - Headache

Serious or Rare Side Effects: - Anaphylactic or severe allergic reactions - Stevens‑Johnson syndrome or toxic epidermal necrolysis - Clostridioides difficile‑associated colitis - Hemolytic anemia - Thrombocytopenia - Acute interstitial nephritis

Cefazolin should be used with careful clinical assessment and monitoring. - Allergy assessment: avoid in patients with known cephalosporin or severe penicillin hypersensitivity. - Renal function: adjust dose in patients with impaired kidney function to prevent accumulation. - Hepatic monitoring: observe liver function tests during prolonged therapy. - Pregnancy and lactation: use only if the potential benefit justifies the potential risk, as safety data are limited. - Concomitant nephrotoxic drugs: monitor renal parameters when combined with other nephrotoxic agents. - Store at below 25°C: keep in the original container, protect from moisture and light.

Cefazolin may interact with other medicines, requiring attention to dosage and monitoring.

Major Interactions (Avoid): - Probenecid: reduces renal excretion of cefazolin, increasing serum concentrations and toxicity risk. - Aminoglycosides: combined use can heighten nephrotoxicity. - Loop diuretics: may exacerbate renal impairment when used together.

Moderate Interactions (Monitor Closely): - Warfarin: cefazolin can potentiate anticoagulant effect, requiring INR monitoring. - Oral contraceptives: may decrease hormonal efficacy, advise alternative contraception. - Methotrexate: concurrent use can raise methotrexate levels, necessitating serum level checks.