Nebivolol/Hydrochlorothiazide Viatris (Hydrochlorothiazide, Nebivolol)

Nebivolol/Hydrochlorothiazide, the active ingredient in Nebivolol/Hydrochlorothiazide Viatris, is a beta‑blocker and thiazide diuretic presented as a tablet for oral use. It is used to lower blood pressure in adults with hypertension.

GNH USA supplies Nebivolol/Hydrochlorothiazide Viatris as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Nebivolol/Hydrochlorothiazide is an antihypertensive agent that acts on the cardiovascular system to control elevated blood pressure.

- Essential hypertension: reduces systolic and diastolic pressure in patients with primary high blood pressure. - Isolated systolic hypertension: lowers elevated systolic readings, especially in older adults. - Diastolic hypertension: helps bring high diastolic values into the target range.

Common Side Effects: - Headache: mild to moderate intensity. - Dizziness or light‑headedness: especially on standing. - Fatigue: general tiredness. - Cough: dry or productive. - Electrolyte disturbances: low potassium or sodium. - Increased urination: due to diuretic effect.

Serious or Rare Side Effects: - Severe hypotension: marked drop in blood pressure. - Bradycardia: unusually slow heart rate. - Acute kidney injury: reduced renal function. - Hyperglycaemia: elevated blood sugar levels. - Allergic reactions: rash, itching, swelling. - Electrolyte imbalance: significant hyponatraemia or hypokalaemia.

Before initiating therapy, consider the following precautions.

- Renal impairment: assess kidney function and adjust dosage if needed. - Hepatic disease: monitor liver enzymes and use with caution. - Electrolyte monitoring: check potassium and sodium levels regularly. - Diabetes mellitus: watch for changes in blood glucose control. - Gout: be aware of potential uric acid elevation. - Store at ambient temperature: keep below 25 °C, retain in original packaging, protect from moisture.

Nebivolol/Hydrochlorothiazide may interact with several medicines; review patient medication lists.

Major Interactions (Avoid): - Strong CYP2D6 inhibitors (e.g., fluoxetine, paroxetine): may increase nebivolol levels. - Lithium: thiazide component can raise lithium concentrations, risking toxicity. - Non‑steroidal anti‑inflammatory drugs (NSAIDs): may blunt diuretic effect and impair renal function.

Moderate Interactions (Monitor Closely): - Other antihypertensives: additive blood‑pressure lowering effect. - Antidiabetic agents: possible need for dose adjustment due to altered glucose control. - Calcium channel blockers (e.g., verapamil): may increase nebivolol plasma concentration.