Nebivolol/Hydrochlorothiazide Biogaran (Hydrochlorothiazide, Nebivolol)

Nebivolol, the active ingredient in Nebivolol/Hydrochlorothiazide Biogaran, is a beta‑blocker presented as a combined oral tablet for oral use. In combination with hydrochlorothiazide, a thiazide diuretic, the formulation reduces cardiac output and plasma volume, providing effective blood‑pressure control for adult patients diagnosed with hypertension.

GNH USA supplies Nebivolol/Hydrochlorothiazide Biogaran as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Nebivolol/Hydrochlorothiazide acts on the cardiovascular system to manage elevated blood pressure. - Hypertension: lowers systolic and diastolic blood pressure in adults with essential hypertension. - Hypertensive chronic kidney disease: assists in controlling blood pressure to slow renal progression. - Hypertension with diabetes: provides blood‑pressure reduction without adversely affecting glucose metabolism.

Common Side Effects: - Dizziness: light‑headed sensation, especially after standing. - Headache: mild to moderate intensity. - Fatigue: feeling of tiredness or reduced energy. - Increased urination: due to diuretic effect. - Electrolyte imbalance: mild changes in potassium or sodium levels.

Serious or Rare Side Effects: - Severe hypotension: markedly low blood pressure requiring medical attention. - Acute renal impairment: sudden decline in kidney function. - Hyperuricemia or gout flare: elevated uric acid levels. - Allergic reactions: rash, itching, or swelling of face and throat.

Before initiating therapy, consider the following precautions: - Monitor blood pressure: ensure adequate control and avoid excessive drops. - Assess renal function: check creatinine and eGFR periodically. - Check electrolytes: especially potassium and sodium levels. - Avoid abrupt discontinuation: taper to prevent rebound hypertension. - Caution in asthma or severe COPD: β1‑selectivity may still affect bronchial tone. - Store at below 25°C: keep in the original packaging, protect from moisture and direct sunlight.

Nebivolol/Hydrochlorothiazide may interact with several drug classes. Major Interactions (Avoid): - Concomitant antihypertensives (e.g., ACE inhibitors, ARBs): risk of additive hypotension. - Potassium‑sparing diuretics or supplements: may cause hyperkalemia. - Non‑steroidal anti‑inflammatory drugs (NSAIDs): can diminish diuretic efficacy and affect renal function. Moderate Interactions (Monitor Closely): - β‑agonist bronchodilators: may reduce β‑blocker effectiveness. - Lithium: diuretic may increase lithium levels, requiring monitoring. - Antidiabetic agents: blood‑glucose may fall, necessitating dose adjustments.