Nebivolol/Hct Stada Arzneimittel Ag (Hydrochlorothiazide, Nebivolol)

Nebivolol, the active ingredient in Nebivolol/Hydrochlorothiazide, is a beta‑blocker presented as an oral tablet for oral use. It is combined with hydrochlorothiazide, a thiazide diuretic, to treat hypertension in adult patients. The combination lowers blood pressure by reducing heart rate and decreasing plasma volume.

GNH USA supplies Nebivolol/Hydrochlorothiazide as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Nebivolol/Hydrochlorothiazide is indicated for the management of high blood pressure within the antihypertensive drug class. - Essential hypertension: reduces systolic and diastolic blood pressure to target levels. - Secondary hypertension: assists in controlling blood pressure when caused by other conditions. - Isolated systolic hypertension: helps lower elevated systolic pressure in older adults.

Common Side Effects: - Dizziness: sensation of light‑headedness, especially after standing. - Headache: mild to moderate pain in the head region. - Fatigue: feeling unusually tired or weak. - Increased urination: more frequent need to void. - Nausea: upset stomach or urge to vomit. - Dry mouth: reduced salivation.

Serious or Rare Side Effects: - Severe hypotension: dangerously low blood pressure requiring medical attention. - Electrolyte imbalance: abnormal potassium or sodium levels. - Acute kidney injury: sudden reduction in kidney function. - Allergic reactions: rash, itching, swelling, or difficulty breathing. - Pancreatitis: inflammation of the pancreas presenting with abdominal pain. - Bradycardia: abnormally slow heart rate.

Before initiating therapy, consider the following precautions: - Monitor blood pressure: check regularly to ensure therapeutic response. - Assess renal function: evaluate kidney performance, especially in patients with pre‑existing disease. - Check electrolytes: watch for potassium or sodium disturbances. - Use caution in diabetes: beta‑blockade may mask hypoglycaemia symptoms. - Avoid abrupt discontinuation: taper gradually to prevent rebound hypertension. - Store at ambient temperature: keep in the original pack, protect from moisture and direct sunlight.

Nebivolol/Hydrochlorothiazide may interact with several medicines. Major Interactions (Avoid): - Other beta‑blockers: additive cardiac depression. - Potent CYP2D6 inhibitors (e.g., paroxetine, quinidine): increase nebivolol plasma levels. - Loop diuretics: excessive diuresis and electrolyte loss. - NSAIDs: may reduce antihypertensive efficacy. - Lithium: increased lithium concentrations. Moderate Interactions (Monitor Closely): - ACE inhibitors or ARBs: risk of hyperkalaemia and renal impairment. - Calcium channel blockers: possible additive blood‑pressure effect. - Antidiabetic agents: may require dose adjustment due to masked hypoglycaemia. - Antidepressants (SSRIs): monitor for bradycardia. - Antimicrobials (e.g., macrolides): observe for QT prolongation.