Nebivolol Comp. Abz (Hydrochlorothiazide, Nebivolol)

Nebivolol/Hydrochlorothiazide, the active ingredients in Nebivolol Comp. Abz, are a beta‑blocker and thiazide diuretic presented as oral tablets for oral use. They treat hypertension in adult patients.

GNH USA supplies Nebivolol Comp. Abz as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Nebivolol/Hydrochlorothiazide is indicated for the management of hypertension, a condition characterized by elevated arterial pressure.

- Essential hypertension: lowers systolic and diastolic blood pressure to target levels. - Secondary hypertension: assists in blood pressure control when fluid retention contributes to the condition. - High blood pressure: helps achieve recommended blood pressure goals as part of combination therapy.

The combination may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects: - Headache: mild to moderate intensity. - Dizziness or light‑headedness: especially after first doses. - Fatigue: general feeling of tiredness. - Increased urination: due to diuretic effect.

Serious or Rare Side Effects: - Severe hypotension: marked drop in blood pressure leading to fainting. - Electrolyte imbalance: low potassium or sodium levels. - Acute kidney injury: sudden decline in renal function.

Before prescribing Nebivolol/Hydrochlorothiazide, consider the following precautions.

- Renal impairment: monitor kidney function and adjust therapy as needed. - Electrolyte disturbances: check serum potassium and sodium regularly. - Diabetes mellitus: may mask hypoglycaemia symptoms; monitor glucose. - Concomitant β‑blockers: avoid additive cardiac depression. - Pregnancy and lactation: use only if benefits outweigh risks; consult specialist. - Store at ambient temperature: keep below 25 °C in original packaging, protect from moisture.

Nebivolol/Hydrochlorothiazide can interact with several medicines; awareness of major and moderate interactions helps ensure safety.

Major Interactions (Avoid): - Combined use with other β‑blockers: may cause excessive bradycardia or heart block. - Strong CYP2D6 inhibitors (e.g., paroxetine, fluoxetine): increase nebivolol plasma levels. - Lithium: thiazide component reduces lithium clearance, raising toxicity risk.

Moderate Interactions (Monitor Closely): - NSAIDs (e.g., ibuprofen): may blunt diuretic antihypertensive effect. - ACE inhibitors or ARBs: risk of additive potassium elevation and renal impairment. - Antidiabetic drugs: diuretic may affect glucose control; monitor blood sugar.