Nebilet Plus (Hydrochlorothiazide, Nebivolol)

Nebivolol and Hydrochlorothiazide, the active ingredients in Nebilet Plus, are a beta‑blocker and a thiazide diuretic presented as tablets for oral use. They work together to lower blood pressure by reducing heart rate and decreasing plasma volume, providing antihypertensive therapy for adult patients with primary hypertension.

GNH USA supplies Nebilet Plus as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, with manufacturing adhering to EU standards and rigorous quality control through reliable distribution networks and timely delivery.

Nebilet Plus combines a beta‑blocker and a thiazide diuretic to manage hypertension, a major cardiovascular condition.

- Hypertension: lowers systolic and diastolic blood pressure in adults with primary hypertension. - Hypertensive edema: reduces fluid retention associated with elevated blood pressure. - Cardiovascular risk reduction: helps decrease the likelihood of stroke and heart attack in patients with uncontrolled hypertension.

Common Side Effects: - Dizziness or light‑headedness - Headache - Fatigue or weakness - Increased urination - Electrolyte disturbances (e.g., low potassium) - Mild gastrointestinal discomfort

Serious or Rare Side Effects: - Severe hypotension - Acute kidney injury or worsening renal function - Significant electrolyte imbalance (hyper‑ or hypokalemia) - Allergic reactions such as rash, angioedema, or anaphylaxis - Pancreatitis (rare)

Nebilet Plus should be used under medical supervision with regular monitoring.

- Blood pressure monitoring: ensure target levels are achieved without excessive drop. - Renal function: assess creatinine and eGFR before and during therapy. - Electrolyte assessment: check serum potassium and sodium periodically. - Diabetes: monitor blood glucose as beta‑blockers may mask hypoglycaemia symptoms. - Abrupt discontinuation: taper dose to avoid rebound hypertension. - Store at ambient temperature: keep below 25°C, retain in original packaging, protect from moisture.

Nebilet Plus may interact with several medicines; careful review is required.

Major Interactions (Avoid): - Other antihypertensives (e.g., ACE inhibitors, ARBs) – risk of profound hypotension. - NSAIDs – may diminish diuretic efficacy and affect renal function. - Lithium – increased lithium levels leading to toxicity. - Potassium‑sparing diuretics – risk of hyperkalaemia. - Strong CYP2D6 inhibitors – elevate nebivolol plasma concentrations.

Moderate Interactions (Monitor Closely): - Calcium channel blockers – additive blood‑pressure lowering effect. - Other beta‑blockers – may cause excessive β‑blockade. - Antidiabetic agents – monitor glucose as beta‑blockers can mask hypoglycaemia. - Antidepressants (e.g., SSRIs) – watch for additive bradycardia. - Diuretics of other classes – monitor electrolytes and renal function.