Nebilet Plus (Hydrochlorothiazide, Nebivolol)

Nebivolol, the active ingredient in Nebilet Plus, is a beta‑blocker presented as an oral tablet for oral use. It is combined with hydrochlorothiazide, a thiazide diuretic, to treat hypertension in adult patients. The dual action helps lower blood pressure by reducing heart rate and decreasing plasma volume.

GNH USA supplies Nebilet Plus as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Nebilet Plus is indicated for the management of high blood pressure within the antihypertensive drug class.

- Essential hypertension: reduces systolic and diastolic pressure to target levels. - Secondary hypertension: assists in controlling blood pressure when caused by another condition. - Isolated systolic hypertension: helps lower elevated systolic readings in older adults.

Nebilet Plus may cause a range of adverse reactions, most of which are mild and transient.

Common Side Effects: - Headache: mild to moderate intensity. - Dizziness or light‑headedness: especially on standing. - Fatigue: general tiredness. - Increased urination: due to diuretic effect. - Electrolyte imbalance: low potassium or sodium. - Cough: occasional dry cough.

Serious or Rare Side Effects: - Severe hypotension: marked drop in blood pressure. - Bradycardia: abnormally slow heart rate. - Acute kidney injury: reduced renal function. - Allergic reactions: rash, itching, or swelling. - Hyperglycaemia: elevated blood glucose levels. - Electrolyte disturbances: severe hyponatraemia or hypokalaemia.

Before initiating therapy with Nebilet Plus, consider the following safety measures.

- Renal impairment: assess kidney function and monitor electrolytes. - Hepatic disease: use with caution in patients with liver dysfunction. - Diabetes mellitus: monitor blood glucose as diuretics may affect control. - Gout: watch for increased uric acid levels. - Pregnancy and lactation: evaluate risk‑benefit ratio; use only if clearly needed. - Store at ambient temperature: keep in original packaging, protect from moisture and direct sunlight.

Nebilet Plus can interact with several medicines; awareness of these interactions helps maintain therapeutic effectiveness.

Major Interactions (Avoid): - Strong CYP2D6 inhibitors (e.g., fluoxetine, paroxetine): may increase nebivolol levels. - Other antihypertensives (e.g., ACE inhibitors, ARBs): risk of excessive blood‑pressure lowering. - Lithium: thiazide component can raise lithium concentrations.

Moderate Interactions (Monitor Closely): - Non‑steroidal anti‑inflammatory drugs (NSAIDs): may reduce diuretic efficacy. - Antidiabetic agents: thiazide may impair glucose control. - Calcium channel blockers: additive effect on heart rate and blood pressure.