GNH USA

Europe — EMA

Nebilet (Nebivolol)

GNH USA supplies Nebilet (Nebivolol), a beta blocker for hypertension and heart failure. Request a quote for global supply. Available as tablets, EU‑made.

Nebivolol

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1
Pack/s

What is Nebivolol?

Nebivolol, the active ingredient in Nebilet, is a beta blocker presented as an oral tablet for oral use. It treats hypertension and heart failure in adult patients. GNH USA supplies Nebilet as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

What is Nebivolol used for?

Nebivolol is indicated for conditions within the cardiovascular disease pathway. - Hypertension: lowers blood pressure and reduces cardiovascular risk. - Heart failure: improves left ventricular function and decreases hospitalization rates.

What are the side effects of Nebivolol?

Nebivolol may cause a range of adverse reactions.

Common Side Effects: - Headache - Dizziness - Fatigue - Nasal congestion - Bradycardia - Nausea

Serious or Rare Side Effects: - Severe bradycardia or heart block - Acute worsening of heart failure - Marked hypotension - Bronchospasm, especially in asthmatic patients - Allergic reactions such as rash or angioedema - Cardiogenic shock

What precautions apply to Nebivolol?

Before initiating nebivolol, consider the following precautions. - Monitor blood pressure: check regularly during initiation and dose adjustments. - Assess cardiac rhythm: avoid in patients with severe bradycardia or advanced AV block. - Caution in asthma or COPD: β‑blockade may worsen bronchospasm. - Adjust for renal or hepatic impairment: dose may need modification. - Pregnancy and lactation: use only if clearly needed after risk‑benefit evaluation. - Store at room temperature: keep in the original pack, protect from moisture and light.

What does Nebivolol interact with?

Nebivolol can interact with several drug classes; awareness helps prevent adverse events.

Major Interactions (Avoid): - Other β‑blockers: risk of excessive bradycardia. - Calcium channel blockers (verapamil, diltiazem): may cause AV‑block. - Strong CYP2D6 inhibitors (paroxetine, fluoxetine): increase nebivolol plasma levels. - Non‑selective β‑agonists (albuterol): may reduce therapeutic effect. - Antihypertensives (clonidine) abrupt withdrawal: can trigger rebound hypertension.

Moderate Interactions (Monitor Closely): - Diuretics: may enhance hypotensive effect. - Antidiabetic agents: nebivolol can mask hypoglycaemia symptoms. - NSAIDs: may attenuate antihypertensive response. - Other antidepressants: monitor blood pressure changes. - Statins: observe for muscle‑related adverse events.

Frequently asked questions

What is Nebilet used for?+
Nebilet contains nebivolol, a selective β1‑adrenergic blocker approved for the treatment of essential hypertension and for chronic heart failure in adults. It helps lower elevated blood pressure and improves cardiac function, thereby reducing the risk of cardiovascular events in these patient groups.
How does nebivolol work?+
Nebivolol works by selectively antagonising β1‑adrenergic receptors in the heart, which slows heart rate and reduces contractility. In addition, it enhances endothelial nitric oxide release, causing vasodilation and lowering peripheral vascular resistance. This dual action contributes to its antihypertensive and heart‑failure benefits.
What is the usual dose of Nebilet?+
The dose of nebivolol is individualized by the prescribing clinician based on the patient’s clinical condition, blood pressure response, and tolerability. Physicians start with a low dose and may titrate upward as needed; exact dosing regimens should always follow the prescriber’s instructions.
Is nebivolol safe in pregnancy or breastfeeding?+
Safety data for nebivolol during pregnancy and lactation are limited. It should only be used when the potential maternal benefit justifies any possible risk to the fetus or infant. Women who are pregnant, planning pregnancy, or breastfeeding should discuss risks and alternatives with their healthcare provider.
How do I order Nebilet from GNH USA?+
To request Nebilet, submit an enquiry on the product page at gnh-usa.com, specifying the required quantity. GNH USA supplies hospitals, pharmacies and procurement teams worldwide, and will ask for trade or institutional credentials. The team then replies with pricing, availability, shipping details (including any cold‑chain requirements) and the necessary import documentation.
How does nebivolol compare with other beta blockers?+
Nebivolol is a highly selective β1‑blocker with additional nitric‑oxide‑mediated vasodilatory properties, which may result in better tolerability, especially regarding metabolic effects and sexual dysfunction. Compared with non‑selective beta blockers, nebivolol often produces fewer bronchospastic events and may have a more favourable impact on endothelial function.
How should Nebilet be stored and handled?+
Nebilet tablets should be stored at room temperature, below 25 °C, in the original container to protect them from moisture and light. Keep the product out of reach of children and avoid storing in humid or excessively hot environments.
How is Nebilet administered?+
Nebilet is taken orally as a whole tablet, swallowed with a glass of water. It may be taken with or without food, but the same conditions should be maintained daily to ensure consistent absorption. Patients should follow the dosing schedule prescribed by their clinician.
What are the most serious risks associated with nebivolol?+
Serious adverse events include severe bradycardia, high‑grade atrioventricular block, marked hypotension, acute worsening of heart failure, bronchospasm in susceptible individuals, and rare allergic reactions such as angioedema. Prompt medical attention is required if any of these symptoms occur.
Who should not use Nebilet?+
Nebilet is contraindicated in patients with severe bradycardia (heart rate <50 bpm), second‑ or third‑degree AV block, cardiogenic shock, uncontrolled asthma or severe chronic obstructive pulmonary disease, and in those with known hypersensitivity to nebivolol or any excipients. Clinicians should assess each patient’s medical history before prescribing.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
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Product details

Drug
Nebivolol
Route
Oral Use
Manufacturer
Menarini International Operations Luxembourg S.A.
Origin
EU

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