Naxalgan (Pregabalin)

Pregabalin, the active ingredient in Naxalgan, is a gabapentinoid presented as an oral tablet for oral use. It is used to manage neuropathic pain, seizures, fibromyalgia, and generalized anxiety disorder in adults.

GNH USA supplies Naxalgan as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Pregabalin is indicated for several neurological and pain‑related conditions.

- Neuropathic pain: reduces pain intensity in diabetic peripheral neuropathy and post‑herpetic neuralgia. - Fibromyalgia: alleviates widespread musculoskeletal pain and improves functional capacity. - Partial seizures: used as adjunct therapy to control focal onset seizures. - Generalized anxiety disorder: decreases anxiety symptoms in adult patients.

Pregabalin may cause a range of adverse reactions, from mild to serious.

Common Side Effects: - Dizziness: sensation of light‑headedness or unsteadiness. - Somnolence: increased sleepiness or fatigue. - Peripheral edema: swelling of the lower extremities. - Weight gain: gradual increase in body weight. - Blurred vision: temporary visual disturbances. - Dry mouth: reduced salivary flow.

Serious or Rare Side Effects: - Angioedema: rapid swelling of face, lips, tongue, or throat. - Severe rash or Stevens‑Johnson syndrome: extensive skin reactions. - Suicidal thoughts or behavior: new or worsening mood changes. - Respiratory depression: slowed breathing, especially with CNS depressants. - Hypersensitivity reactions: anaphylaxis or severe allergic response. - Blood dyscrasias: rare cases of leukopenia or thrombocytopenia.

When prescribing or dispensing Pregabalin, several safety considerations are important.

- Renal impairment: adjust dose based on creatinine clearance. - Pregnancy: discuss potential risks with a healthcare professional; data are limited. - CNS depression: avoid concomitant alcohol or sedatives that may enhance drowsiness. - Suicidality: monitor patients for mood changes or emergent suicidal thoughts. - Withdrawal: taper gradually to reduce the risk of rebound symptoms. - Store at room temperature: keep in the original container, protect from moisture and direct sunlight.

Pregabalin can interact with other medicines, requiring attention to avoid adverse outcomes.

Major Interactions (Avoid): - Opioids: combined use may increase risk of respiratory depression. - CNS depressants (e.g., benzodiazepines): may enhance sedation and dizziness. - Antacids containing aluminum or magnesium: can reduce Pregabalin absorption.

Moderate Interactions (Monitor Closely): - NSAIDs: concurrent use may heighten risk of renal impairment. - Diuretics: may increase serum Pregabalin concentrations. - Antihypertensives: potential additive hypotensive effect.