GNH USA

Europe — EMA

Navelbine (Vinorelbine Tartrate)

GNH USA supplies Navelbine (Vinorelbine tartrate), a Vinca alkaloid for non‑small cell lung cancer and metastatic breast cancer. Request a quote for supply.

Vinorelbine Tartrate

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What is Vinorelbine Tartrate?

Vinorelbine tartrate, the active ingredient in Navelbine, is a Vinca alkaloid presented as a capsule for oral use. It treats non‑small cell lung cancer and metastatic breast cancer in adult patients.

GNH USA supplies Navelbine as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, oncology centres and pharmacies worldwide.

What is Vinorelbine Tartrate used for?

Vinorelbine tartrate (Navelbine) is employed in the management of solid tumours that depend on microtubule dynamics.

Non‑small cell lung cancer: improves disease control and overall survival in adult patients. Metastatic breast cancer: reduces tumour burden and extends progression‑free survival in advanced disease.

What are the side effects of Vinorelbine Tartrate?

Vinorelbine may cause a range of adverse reactions that vary in frequency and severity.

Common Side Effects: - Nausea: mild to moderate gastrointestinal upset. - Neutropenia: reduced white‑blood‑cell count increasing infection risk. - Fatigue: persistent sense of tiredness. - Constipation: decreased bowel movements.

Serious or Rare Side Effects: - Severe neutropenia with fever: heightened risk of life‑threatening infection. - Pulmonary toxicity: cough, dyspnoea, or interstitial infiltrates. - Peripheral neuropathy: tingling, numbness, or pain in extremities. - Allergic reaction: rash, itching, or anaphylaxis.

What precautions apply to Vinorelbine Tartrate?

Before initiating therapy, clinicians should assess patient suitability and monitor for known risks. - Monitor blood counts: perform regular complete blood count to detect neutropenia. - Assess liver function: adjust dosing if hepatic impairment is present. - Avoid in active severe infection: postpone treatment until infection resolves. - Use effective contraception: teratogenic potential is unknown. - Store at below 25°C: keep in the original pack, protect from moisture.

What does Vinorelbine Tartrate interact with?

Vinorelbine can interact with other medicines, altering its efficacy or safety.

Major Interactions (Avoid): - Strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole): may increase vinorelbine exposure. - Concurrent myelosuppressive chemotherapy: heightens risk of severe bone‑marrow suppression.

Moderate Interactions (Monitor Closely): - CYP3A4 inducers (e.g., rifampicin, carbamazepine): may reduce therapeutic levels. - Antiemetics such as ondansetron: may require dose adjustment. - Anticoagulants (e.g., warfarin): monitor coagulation parameters. - NSAIDs: increase risk of gastrointestinal bleeding.

Frequently asked questions

What is Navelbine used for?+
Navelbine (vinorelbine tartrate) is an antineoplastic agent indicated for the treatment of adult patients with non‑small cell lung cancer and metastatic breast cancer. It is part of chemotherapy regimens that target rapidly dividing tumour cells.
How does vinorelbine tartrate work?+
Vinorelbine tartrate binds to tubulin, inhibiting microtubule assembly. This blocks the formation of the mitotic spindle, arresting cells in the M phase of the cell cycle and ultimately leading to apoptosis of cancer cells that rely on microtubule dynamics for division.
What is the usual dose of Navelbine?+
The prescribed dose of Navelbine is determined by the treating oncologist based on the patient’s clinical condition, body surface area, and treatment protocol. Dosage adjustments may be required for hepatic function, blood‑count levels, or concomitant therapies.
Is Navelbine safe during pregnancy or breastfeeding?+
The safety of vinorelbine tartrate in pregnancy and lactation has not been established. It is generally advised to avoid use in pregnant or nursing women unless the potential benefit justifies the potential risk to the fetus or infant.
How do I order Navelbine from GNH USA?+
To order Navelbine, submit an enquiry on the product page at gnh-usa.com specifying the required quantity. GNH USA supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any required import documentation.
How does Navelbine compare with other chemotherapy agents?+
Vinorelbine belongs to the Vinca alkaloid class, which differs from taxane‑based agents by targeting tubulin assembly at a distinct binding site. Compared with other Vinca alkaloids, vinorelbine has a more favourable toxicity profile for certain patients, but choice of therapy depends on tumour type, prior treatment and individual tolerance.
What are the storage and handling requirements for Navelbine?+
Navelbine capsules should be stored at temperatures below 25 °C, in the original container, protected from moisture and direct sunlight. Keep the product out of reach of children and avoid exposure to excessive heat or humidity.
How is Navelbine administered?+
Navelbine is taken orally as a capsule. The capsule should be swallowed whole with water, preferably on an empty stomach or as directed by the prescribing physician. Administration timing may be coordinated with other chemotherapy agents in a treatment cycle.
What are the most serious risks associated with Navelbine?+
The most serious risks include severe neutropenia with fever, which can lead to life‑threatening infections, pulmonary toxicity presenting as cough or dyspnoea, and rare allergic reactions such as anaphylaxis. Patients should be monitored closely for signs of infection, respiratory changes, or hypersensitivity.
Who should not use Navelbine?+
Navelbine should not be used in patients with known hypersensitivity to vinorelbine or other Vinca alkaloids, in those with severe bone‑marrow suppression, uncontrolled infections, or significant hepatic impairment without dose adjustment. It is also contraindicated during pregnancy unless the benefits outweigh the risks.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
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Product details

Drug
Vinorelbine Tartrate
Route
Oral Use
Manufacturer
Pierre Fabre Medicament
Origin
EU

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